Trace elements and toxic heavy metals play a role in Buerger disease and atherosclerotic peripheral arterial occlusive disease

Basit Öğe Kaydı
dc.authorscopusid7004214393
dc.authorscopusid25930249000
dc.authorscopusid37053534300
dc.authorscopusid6508166517
dc.authorscopusid8713588200
dc.authorscopusid23968920100
dc.authorscopusid6603239395
dc.authorwosidBozkurt, Ahmet Kürşat/AAD-1464-2021
dc.contributor.authorArslan, C.
dc.contributor.authorAltan, H.
dc.contributor.authorAkgün, O. O.
dc.contributor.authorKızıler, Ali Rıza
dc.contributor.authorAydemir, Birsen
dc.contributor.authorGüzel, Savaş
dc.contributor.authorBozkurt, A. K.
dc.date.accessioned2022-05-11T14:14:05Z
dc.date.available2022-05-11T14:14:05Z
dc.date.issued2010
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractAim. The aim of the present study was to define the roles of trace elements and toxic heavy metals in Buerger disease and atherosclerotic peripheral arterial occlusive disease (PAOD). Methods. Seventy-five subjects who were identical in demographic charecteristics were selected for the study; 25 with Buerger disease, 25 with PAOD, 25 healthy volunteers. Serum selenium (Se), zinc (Zn), copper (Cu), iron (Fe),whole blood cadmium (Cd) and lead (Pb), erythrocyte glutathione (GSH), erythrocyte glutathione peroxidase (GSH-Px), erythrocyte and plasma malondialdehyde (MDA) levels were measured. Results. Serum Se and Zn levels were significantly low in patients with Buerger disease compared to patients with PAOD and controls (P<0.001 and P<0.001 respectively). Serum levels of Fe and Zn were also significantly low in patients with PAOD compared to controls (p<0.001 and p<0.05 respectively). In contrast, Cu and Pb levels in Buerger disease group were significantly high compared to PAOD and control groups (P<0.001 and P<0.001 respectively). Erythrocyte GSH and GSH-Px levels were significantly lower in patients with Buerger disease compared to patients with PAOD and controls (P<0.001 and P<0.001 respectively), while erythrocyte and plasma MDA levels were significantly higher (P<0.001 and P<0.001 respectively). Conclusions. It can be concluded that the levels of trace elments and toxic heavy metals and oxidative stress influence the disease process in Buerger disease more than PAOD. [Int Angiol 2010;29:489-95]
dc.identifier.endpage495
dc.identifier.issn0392-9590
dc.identifier.issn1827-1839
dc.identifier.issue6en_US
dc.identifier.pmid21173730
dc.identifier.scopus2-s2.0-79952309634
dc.identifier.scopusqualityQ3
dc.identifier.startpage489
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5778
dc.identifier.volume29
dc.identifier.wosWOS:000287944100003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKızıler, Ali Rıza
dc.institutionauthorGüzel, Savaş
dc.language.isoen
dc.publisherEdizioni Minerva Medica
dc.relation.ispartofInternational Angiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTrace elements
dc.subjectMetals, heavy
dc.subjectThromboangiitis obliterans
dc.subjectActivated Receptor-Alpha
dc.subjectEndothelial-Cells
dc.subjectOxidative Stress
dc.subjectBlood Lead
dc.subjectZinc
dc.subjectCopper
dc.subjectRisk
dc.subjectSelenium
dc.subjectCadmium
dc.subjectAtherogenesis
dc.titleTrace elements and toxic heavy metals play a role in Buerger disease and atherosclerotic peripheral arterial occlusive disease
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu