The Effects of Quercetin on Acute Lung Injury and Biomarkers of Inflammation and Oxidative Stress in the Rat Model of Sepsis

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dc.authorid0000-0003-4819-9963
dc.authorid0000-0002-1347-8498
dc.authorid0000-0002-2270-2965
dc.authorscopusid16042227300
dc.authorscopusid55515412500
dc.authorscopusid47561031200
dc.authorscopusid55858591400
dc.authorscopusid56870958100
dc.authorscopusid6701664660
dc.authorscopusid36866111300
dc.authorwosidAYDIN, BAYRAM OĞUZ/AAL-1136-2020
dc.authorwosidsener, umit/AAZ-7728-2020
dc.authorwosidUzun, Hafize/D-4811-2019
dc.authorwosidYilmaz, Ahsen/ABB-1083-2021
dc.contributor.authorGerin, Fethullah
dc.contributor.authorŞener, Ümit
dc.contributor.authorErman, Hayriye
dc.contributor.authorYılmaz, Ahsen
dc.contributor.authorAydın, Bayram
dc.contributor.authorArmutcu, Ferah
dc.contributor.authorGürel, Ahmet
dc.date.accessioned2022-05-11T14:14:01Z
dc.date.available2022-05-11T14:14:01Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.description.abstractExperimental studies indicate that sepsis causes remote organ injury although the molecular mechanism has not been clearly defined. In this report, the role of oxidative damage, and inflammation on lung injury, following sepsis model by cecal ligation and puncture, and the effects of quercetin, antioxidant, and anti-inflammatory flavonoid, in the lung tissue were investigated. In the present study, we found that administration of single-dose quercetin before cecal ligation and puncture procedure, while markedly diminishing the levels of YKL-40 and oxidant molecules (xanthine oxidase (XO), nitric oxide (NO), and malondialdehyde (MDA)), increases the antioxidant enzymes levels. Quercetin is beneficial to acute lung injury by decreasing the levels of oxidative stress markers and increasing the antioxidant enzyme activities. Quercetin also causes a decrease in the serum levels of YKL-40 and periostin in the oxidative lung injury induced by the experimental sepsis model.
dc.identifier.doi10.1007/s10753-015-0296-9
dc.identifier.endpage705
dc.identifier.issn0360-3997
dc.identifier.issn1573-2576
dc.identifier.issue2en_US
dc.identifier.pmid26670180
dc.identifier.scopus2-s2.0-84949936012
dc.identifier.scopusqualityQ2
dc.identifier.startpage700
dc.identifier.urihttps://doi.org/10.1007/s10753-015-0296-9
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5743
dc.identifier.volume39
dc.identifier.wosWOS:000374103000023
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGerin, Fethullah
dc.institutionauthorŞener, Ümit
dc.institutionauthorErman, Hayriye
dc.institutionauthorYılmaz, Ahsen
dc.institutionauthorAydın, Bayram
dc.institutionauthorArmutcu, Ferah
dc.institutionauthorGürel, Ahmet
dc.language.isoen
dc.publisherSpringer/Plenum Publishers
dc.relation.ispartofInflammation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectquercetin
dc.subjectoxidative stress
dc.subjectYKL-40
dc.subjectsepsis
dc.subjectVascular Dysfunction
dc.subjectSeptic Shock
dc.subjectPeriostin
dc.subjectYkl-40
dc.subjectMice
dc.subjectProteins
dc.subjectFibrosis
dc.subjectOutcomes
dc.subjectDisease
dc.subjectHealth
dc.titleThe Effects of Quercetin on Acute Lung Injury and Biomarkers of Inflammation and Oxidative Stress in the Rat Model of Sepsis
dc.typeArticle

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