Comparison of Short Term Effects of Risperidone and Paliperidone on Serum Prolactin Levels in Female Patients

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dc.authorwosidBEYAZYUZ, MURAT/ABA-7934-2020
dc.authorwosidAlbayrak, Yakup/ABA-7651-2020
dc.contributor.authorAlbayrak, Yakup
dc.contributor.authorÜnsal, Cüneyt
dc.contributor.authorBeyazyüz, Murat
dc.contributor.authorKuloğlu, Murat
dc.date.accessioned2022-05-11T14:41:04Z
dc.date.available2022-05-11T14:41:04Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: Hyperprolactinemia is an adverse effect, which is related with the use of antipsychotics. All typical antipsychotics are considered to increase serum prolactin levels. Compared with typical antipsychotics, most of the atypical antipsychotics have a reduced tendency for increasing serum prolactin levels. However, effects of all atypical antipsychotics on serum prolactin levels are not always similar. In the present study, we aimed to compare short-term effects of risperidone and paliperidone, which are two similar atypical antipsychotics in terms of hyperprolactinemia and its associated symptoms. Methods: In this study, we screened data of female patients with diagnosis of schizophrenia and other psychotic disorders, bipolar disorder and who were treated with risperidone or paliperidone. The patients who had adequate sociodemographical and clinical data and who had screened in terms of prolactin levels before and fourth week of the treatment were included to study. Results: Forty-two patients have been treated with risperidone and 36 patients have been treated with paliperidone. Treatment groups were similar in terms of sociodemographic variables. The mean values of serum prolactin levels were significantly increased after four weeks of treatment in both groups (p<0.001). The discontinuation rates because of menstrual irregularities, galactorrhea, sexual dysfunction in risperidone and paliperidone groups were 11.9% and 30.6% respectively, and the rate was significantly higher in paliperidone group (chi(2) =4.13, p=0.04). Conclusion: We suggest that beside its benefits and some superiorities compared to risperidone, paliperidone has no advantage over risperidone in terms of hyperprolactinemia and its associated symptoms. We also suggest that female patients should be monitorized regulary in terms of hyperprolactinemia and its associated symptoms while they are being treated with paliperidone. To our knowledge, the present study is the first to compare and demonstrate the effects of paliperidone and risperidone on serum prolactin levels in Turkey. Further studies with larger sample size are needed to highlight the short term and long term effects of paliperidone on serum prolactin levels in female patients.
dc.identifier.doi10.5455/jmood.20130926044115
dc.identifier.endpage13
dc.identifier.issn2146-1473
dc.identifier.issn2146-2380
dc.identifier.issue1en_US
dc.identifier.startpage7
dc.identifier.urihttps://doi.org/10.5455/jmood.20130926044115
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9050
dc.identifier.volume4
dc.identifier.wosWOS:000421340200002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.institutionauthorAlbayrak, Yakup
dc.institutionauthorÜnsal, Cüneyt
dc.language.isoen
dc.publisherYerkure Tanitim & Yayincilik Hizmetleri A S
dc.relation.ispartofJournal of Mood Disorders
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectrisperidone
dc.subjectpaliperidone
dc.subjectprolactin
dc.subjectExtended-Release Tablets
dc.subjectAcute Schizophrenia
dc.subjectPooled Data
dc.subjectEfficacy
dc.subjectHyperprolactinemia
dc.subjectSafety
dc.subjectOlanzapine
dc.subject6-Week
dc.subjectAntipsychotics
dc.subjectHaloperidol
dc.titleComparison of Short Term Effects of Risperidone and Paliperidone on Serum Prolactin Levels in Female Patients
dc.typeArticle

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