Is subclinical hypothyroidism contributing dyslipidemia and insulin resistance in women with polycystic ovary syndrome?
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Date
2012
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis Ltd
Access Rights
info:eu-repo/semantics/closedAccess
Abstract
We aimed to analyze lipid parameters and determine the need for a 2-hour oral glucose tolerance test (OGTT) for the identification of IR and impaired glucose tolerance test (IGT) in subclinical hypothyroidism (SCH) women with and without polycystic ovary syndrome (PCOS). 20 patients with PCOS and SCH consisted of Group I and 39 patients with PCOS and normal thyroid function consisted of Group II and 53 healthy women with normal thyroid function consisted of Group III. Triglyceride levels were 143.26 +/- 99.86 mg/dL in group 1 and 88.56 +/- 37.56 mg/dL in group 2 and 83.71 +/- 31.94 mg/dL in group 3 which were statistically significant. Total cholesterol, HDL-cholesterol, LDL-cholesterol were found similar between the groups. Fasting insulin levels were 12.45 +/- 8.62 mu U/mL in group 1 and 8.60 +/- 5.35 mu U/mL in group 2 and 7.04 +/- 3.55 mu U/mL in group 3 which were statistically significant (P = 0.027). HOMA-IR were 2.92 +/- 2.34 in group 1 and 1.95 +/- 1.52 in group 2 and 1.60 +/- 0.86 in group 3 which were statistically significant (P = 0.046). This study showed that women with PCOS and subclinical hypothyroidism should be evaluated for dyslipidemia and Insulin resistance.
Description
Keywords
Hypothyroidism, insulin resistance, polycystic ovary syndrome, Thyroid-Stimulating Hormone, Glucose, Obesity, Disease
Journal or Series
Gynecological Endocrinology
WoS Q Value
Q3
Scopus Q Value
Q2
Volume
28
Issue
8
