Group VA Aromatic Thiosemicarbazone Complexes: Synthesis, Characterization, Biological Activity, and Topological Studies

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dc.authoridBanti, Christina/0000-0001-6727-2711
dc.contributor.authorOzturk, Ibrahim I.
dc.contributor.authorSumer, Emine I.
dc.contributor.authorDutkiewicz, Grzegorz
dc.contributor.authorBanti, Christina N.
dc.contributor.authorHadjikakou, Sotiris K.
dc.contributor.authorGrzeskiewicz, Anita M.
dc.contributor.authorKubicki, Maciej
dc.date.accessioned2024-10-29T17:59:22Z
dc.date.available2024-10-29T17:59:22Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractThe antiproliferative and antibacterial activities of thiosemicarbazones increase markedly with the presence of metal ions. One of the factors determining the activity of metal thiosemicarbazone complexes is the coordination structure. In this study, the biological effects of new antimony (III) and bismuth (III) thiosemicarbazone complexes with different binding modes and geometrical structures were demonstrated. Three new complexes, with the formulae {[SbCl3(mu 2-S-Hacptsc)(eta 1-S-Hacptsc)], 2/3H2O,1/3CH2Cl2}, {[SbCl3(kappa 2-S,N-Hacpmtsc)(eta 1-S-Hacpmtsc)2CH2Cl2]}, and{[BiCl3(eta 1-S-Hbzmtsc)3]C2H5OH}, where Hacptsc: acetophenone thiosemicarbazone, Hacpmtsc: acetophenone-N-methyl thiosemicarbazone, Hbzmtsc: benzaldehyde-N-methyl thiosemicarbazone) were elucidated by different methods and deeply analyzed in accordance with their structure by X-ray structure analysis and Atoms-In-Molecules topological analysis. This analysis provided a deeper understanding of the coordination spheres of the Sb/Bi complexes. For instance, the first reported two binding modes of the same ligand are observed in a single crystal structure of antimony (III) halide complexes. Additionally, in one of the complexes, a solid-to-solid phase transition was detected and analyzed in detail. Those complexes, very unique in terms of their geometry, have also been tested for their in vitro cytotoxic activity against human adenocarcinoma cervical cancer (HeLa) cells, whereas antimony (III) complex 1is the most active complex of this study. Further, the antibacterial activity of the complexes has been screened against two Gram-negative (Pseudomonas aeruginosa and Escherichia coli) and two Gram-positive (Staphylococcus epidermidis and Staphylococcus aureus) pathogenic bacteria. From the results, it is found that all the complexes exhibited significant activity against the Gram-negative pathogenic bacteria.
dc.description.sponsorshipTekirdag Namimath;k Kemal University Scientific Research Projects Unit [NKUBAP.01.GA.23.452]
dc.description.sponsorshipA part of this study was carried out under the supervision of I.I.O. in partial fulfillment of the requirements of E.I.S.'s master 's thesis. A part of this research was supported by Tekirdag Nam & imath;k Kemal University Scientific Research Projects Unit (Project No. NKUBAP.01.GA.23.452).
dc.identifier.doi10.3390/ijms251910794
dc.identifier.issn1661-6596
dc.identifier.issn1422-0067
dc.identifier.issue19en_US
dc.identifier.pmid39409123
dc.identifier.scopus2-s2.0-85206493399
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/ijms251910794
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14716
dc.identifier.volume25
dc.identifier.wosWOS:001332393000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectantimony (III)
dc.subjectbismuth (III)
dc.subjectaromatic thiosemicarbazones
dc.subjectcrystal structure
dc.subjectbiological studies
dc.titleGroup VA Aromatic Thiosemicarbazone Complexes: Synthesis, Characterization, Biological Activity, and Topological Studies
dc.typeArticle

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