Heteroleptic six-coordinate bismuth(iii) complexes with 2-acetylthiophene thiosemicarbazones: synthesis, characterization, and biological properties

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dc.authoridGrzeskiewicz, Anita M./0000-0003-0377-2260
dc.authoridBanti, Christina/0000-0001-6727-2711
dc.authoridHadjikakou, Sotiris/0000-0001-9556-6266
dc.contributor.authorOzturk, Ibrahim I.
dc.contributor.authorTurk, Kadriye
dc.contributor.authorGrzeskiewicz, Anita M.
dc.contributor.authorKubicki, Maciej
dc.contributor.authorBanti, Christina N.
dc.contributor.authorHadjikakou, Sotiris K.
dc.date.accessioned2024-10-29T17:58:33Z
dc.date.available2024-10-29T17:58:33Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractThe present study aimed to prepare and then evaluate the antiproliferative and antibacterial activities of bismuth(III) thiosemicarbazone complexes. Five bismuth(III) halide complexes of general formulae [BiX3(HL)(3)] (X: Cl; 1 and 2) and [BiX2(mu(2)-X)(HL)(2)](2) (X: Br and I; 3,4 and 5), where HL is a thiosemicarbazone bearing an acetylthiophene moiety, have been synthesized and fully characterized, including their X-ray crystal structures. In all cases, the thiosemicarbazone ligand coordinated in a monodentate mode via the sulfur atom. Complexes 1 and 2 are mononuclear bismuth(III) complexes with octahedral (Oh) geometry around the metal ion formed by three sulfur and three chlorine atoms. However, the coordination mode of the ligands varied around the bismuth centers. Complex 1 contains one molecule with only a meridional orientation in its asymmetric unit, while complex 2 contains two molecules in its asymmetric unit, one with meridional orientation and the other with facial one. Two bismuth(III) atoms in dinuclear complexes (3, 4 and 5) were coordinated with each other by two halogen bridges. The bismuth(III) complexes 1-5 and their free ligands have been tested for their in vitro cytotoxic activity against human adenocarcinoma cervical cancer (HeLa) cells. The complexes showed promising results as antiproliferative agents for the HeLa cell line, with IC50 values ranging from 4.5 +/- 0.4 to 24.3 +/- 1.7 mu M. All these complexes were also tested against a series of bacteria, and they proved to be ineffective against Gram-positive bacteria (S. epidermidis and S. aureus) and moderately active against Gram-negative bacteria (P. aeruginosa and E. coli).
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK) [121Z222]; Tekirdag Namik Kemal University; NKUBAP.01.
dc.description.sponsorshipThis work was supported by The Scientific and Technological Research Council of Turkey (TUBITAK, Project no. 121Z222) and by the Tekirdag Namik Kemal University (Project no. NKUBAP.01.GA.23.452).
dc.identifier.doi10.1039/d3nj01411h
dc.identifier.endpage12789
dc.identifier.issn1144-0546
dc.identifier.issn1369-9261
dc.identifier.issue27en_US
dc.identifier.scopus2-s2.0-85164330285
dc.identifier.scopusqualityQ2
dc.identifier.startpage12779
dc.identifier.urihttps://doi.org/10.1039/d3nj01411h
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14382
dc.identifier.volume47
dc.identifier.wosWOS:001017486100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherRoyal Soc Chemistry
dc.relation.ispartofNew Journal of Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMetal-Complexes
dc.subjectSpectroscopic Properties
dc.subjectCopper(Ii) Complexes
dc.subjectChloride Complexes
dc.subjectCrystal-Structures
dc.subjectDerivatives
dc.titleHeteroleptic six-coordinate bismuth(iii) complexes with 2-acetylthiophene thiosemicarbazones: synthesis, characterization, and biological properties
dc.typeArticle

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