Serum YKL-40 level is correlated with apnea hypopnea index in patients with obstructive sleep apnea syndrome

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dc.authorid0000-0002-3535-5704
dc.authorwosidMutlu, Levent Cem/AAZ-5186-2020
dc.contributor.authorMutlu, Levent Cem
dc.contributor.authorTülübaş, Feti
dc.contributor.authorAlp, Recep
dc.contributor.authorKaplan, Gökhan
dc.contributor.authorYıldız, Zeynep Deniz
dc.contributor.authorGürel, A.
dc.date.accessioned2022-05-11T14:10:07Z
dc.date.available2022-05-11T14:10:07Z
dc.date.issued2017
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractOBJECTIVE: Obstructive sleep apnea syndrome (OSAS) has been associated with elevated biochemical markers of inflammation. Although the exact mechanism is unknown, both sleep deprivation and hypoxemia are believed to be important causative factors. YKL-40, also known as chitinase-like protein, has been shown to be related to various inflammatory conditions including atherosclerosis, diabetes, cancer and asthma. The present study aimed to evaluate the relationship between YKL-40 levels and the Apnea Hypopnea Index (AHI) in patients with obstructive sleep apnea syndrome. PATIENTS AND METHODS: The study was conducted at the Sleep Unit of the Namik Kemal University Research Center. From January 2013 to December 2013, 120 patients diagnosed with OSAS by polysomnography and 40 subjects without OSAS were recruited. Patients in both groups were matched by age, sex, and body mass index (BM!). They were further divided into groups of mild, moderate and severe OSAS based on their AHI value. Serum YKL-40 concentrations were measured by the enzyme linked immunosorbent assay (ELISA). RESULTS: OSAS patients showed significantly elevated YKL-40 levels compared to the control group; 102,05 (23.14) pg/ml in the control group vs. 144.81 (65.53) pg/ml in the OSAS group. A Spearman correlation analysis showed that serum YKL-40 levels were significantly and positively correlated with AHI (r = 0.434, p < 0.001) and oxygen desaturation index (r = 0.374, p < 0.001). CONCLUSIONS: The study demonstrated that high serum YKL-40 levels correlated with the severity of OSAS and might serve as a nonspecific biomarker for prediction and progression of the disease.
dc.identifier.endpage4166
dc.identifier.issn1128-3602
dc.identifier.issue18en_US
dc.identifier.pmid29028081
dc.identifier.scopus2-s2.0-85044820370
dc.identifier.scopusqualityQ2
dc.identifier.startpage4161
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5290
dc.identifier.volume21
dc.identifier.wosWOS:000413483200028
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMutlu, Levent Cem
dc.institutionauthorTülübaş, Feti
dc.institutionauthorAlp, Recep
dc.institutionauthorKaplan, Gökhan
dc.institutionauthorYıldız, Zeynep Deniz
dc.institutionauthorGürel, A.
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectObstructive sleep apnea
dc.subjectYKL-40
dc.subjectInflammatory cytokine
dc.subjectProtein Expression
dc.subjectDisease Severity
dc.subjectBlood-Pressure
dc.subjectHeart Health
dc.subjectAssociation
dc.subjectChitinase
dc.subjectStroke
dc.subjectInflammation
dc.subjectMacrophages
dc.subjectAsthma
dc.titleSerum YKL-40 level is correlated with apnea hypopnea index in patients with obstructive sleep apnea syndrome
dc.typeArticle

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