Antiapoptotic and proliferative activity of curcumin on ovarian follicles in mice exposed to whole body ionizing radiation

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dc.authorscopusid24436194200
dc.authorscopusid7006356462
dc.authorscopusid6603957040
dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorAktaş, Cevat
dc.contributor.authorKanter, Mehmet
dc.contributor.authorKoçak, Zafer
dc.date.accessioned2022-05-11T14:41:25Z
dc.date.available2022-05-11T14:41:25Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractThe aim of this study was to evaluate the antiapoptotic and proliferative activity of curcumin (Cur) on the ovarian follicles in mice exposed to whole body ionizing radiation (Rd). The mice were exposed to 8.3 gray whole body Rd, and Cur groups were given as a daily dose of 100 mg/kg of Cur for 10 days (10 days before Rd). The ovaries were collected 3 and 12 h after irradiation. To date, no such studies have been performed on antiapoptotic and proliferative activity of Cur on the ovarian follicles in mice exposed to whole body Rd. Analysis of mice ovary after exposure to Rd by terminal-deoxynucleotidyl-transferase-mediated dUTP nick end labeling showed that there were apoptotic cells both in the follicular wall and the antrum, and that the number of follicles showing early atresic features was high 3 h after Rd. On the other hand, analysis of mice ovary 12 h after exposure to Rd showed that the number of follicles containing apoptotic cells with advanced atresic features was significantly higher when compared to the 3-h Rd exposure group. The proliferating cell nuclear antigen-positive granulosa cells were decreased in association with follicular atresia. The groups given treatment were observed to have some benefit from Cur against the damage caused by Rd. The results of this study demonstrate that Cur prevents follicular atresia in Rd-induced apoptosis in ovarian follicles.
dc.identifier.doi10.1177/0748233711425080
dc.identifier.endpage863
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue9en_US
dc.identifier.pmid22075690
dc.identifier.scopus2-s2.0-84866348044
dc.identifier.scopusqualityQ3
dc.identifier.startpage852
dc.identifier.urihttps://doi.org/10.1177/0748233711425080
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9177
dc.identifier.volume28
dc.identifier.wosWOS:000308886000009
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAktaş, Cevat
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectIonizing radiation
dc.subjectovarian follicles
dc.subjectapoptosis
dc.subjectTUNEL
dc.subjectPCNA
dc.subjectmice
dc.subjectFollicular Development
dc.subjectMouse Ovary
dc.subjectApoptosis
dc.subjectAtresia
dc.subjectRat
dc.subjectRadioprotection
dc.subjectDegeneration
dc.subjectMechanisms
dc.subjectExpression
dc.subjectTherapy
dc.titleAntiapoptotic and proliferative activity of curcumin on ovarian follicles in mice exposed to whole body ionizing radiation
dc.typeArticle

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