Down-regulation of miRNA 145 and up-regulation of miRNA 4516 may be associated with primary hypertension

Basit Öğe Kaydı
dc.authorid0000-0002-5389-3143
dc.authorid0000-0003-0552-3911
dc.authorscopusid8570900600
dc.authorscopusid6603926071
dc.authorscopusid16039387600
dc.authorscopusid56216377800
dc.authorwosidUlusoy, Sukru/AAL-9150-2021
dc.contributor.authorÖzkan, Gülsüm
dc.contributor.authorUlusoy, Şükrü
dc.contributor.authorGeyik, Elif
dc.contributor.authorErdem, Yunus
dc.date.accessioned2022-05-11T14:39:57Z
dc.date.available2022-05-11T14:39:57Z
dc.date.issued2019
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractComplex mechanisms including genetic factors have been proposed in the pathogenesis of primary hypertension (HT). Micro RNAs (miRNAs) are single-stranded RNA molecules that are not converted into protein products. However, it has been established that genes regulate conversion into protein products. The primary aim of this study was to investigate the roles of miRNA 4516, miRNA 145, miRNA 24, and miRNA 181a in the pathogenesis of HT. The secondary aim was to investigate the relation between these miRNAs and renin, aldosterone, norepinephrine, renalase, and NOS. Fifty-two hypertensive and 51 control normotensive individuals under observation in the Cappadocia cohort were included in the study. miRNA 4516, miRNA 181a, miRNA 24, and miRNA 145 levels were measured using the ddPCR method. miRNA 4516 and norepinephrine levels were significantly higher in the HT group (P < .005 for both), while miRNA 145 levels were significantly lower (<.05). miRNA 4516 up-regulation (P < .05) and miRNA 145 down-regulation (P < .05) were identified as independent predictors of HT. Renalase exhibited negative correlation with miRNA 4516 and positive correlation with miRNA 145 in the patient and control group. In addition, negative correlation was present between miRNA 24 and NE and NOS and between miRNA 181a and NOS in the patient group. Our study identified, for the first time in the literature, miRNA 4516 up-regulation and miRNA 145 down-regulation as independent determinants of HT. Further studies performed in the light of our findings may lead to a better understanding of the pathogenesis and new therapeutic possibilities.
dc.identifier.doi10.1111/jch.13704
dc.identifier.endpage1731
dc.identifier.issn1524-6175
dc.identifier.issn1751-7176
dc.identifier.issue11en_US
dc.identifier.pmid31556476
dc.identifier.scopus2-s2.0-85073964773
dc.identifier.scopusqualityQ2
dc.identifier.startpage1724
dc.identifier.urihttps://doi.org/10.1111/jch.13704
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8809
dc.identifier.volume21
dc.identifier.wosWOS:000495802800020
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÖzkan, Gülsüm
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Clinical Hypertension
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjecthypertension
dc.subjectmiRNA 145
dc.subjectmiRNA 181a
dc.subjectmiRNA 24
dc.subjectmiRNA 4516
dc.subjectBlood-Pressure
dc.subjectOverexpression
dc.subjectQuantification
dc.subjectMicrornas
dc.subjectMir-181a
dc.subjectRenin
dc.titleDown-regulation of miRNA 145 and up-regulation of miRNA 4516 may be associated with primary hypertension
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
8809.pdf
Boyut:
758.46 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu