Synthesis, Characterization, and Biological Investigation of Antimony(III) Halide Complexes With Different Coordination Architectures Constructed From Thiophene Thiosemicarbazones

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dc.authoridUcar, Okan/0000-0001-5921-3324
dc.contributor.authorUcar, Okan
dc.contributor.authorOzturk, Ibrahim I.
dc.contributor.authorGrzeskiewicz, Anita M.
dc.contributor.authorKubicki, Maciej
dc.contributor.authorBanti, Christina N.
dc.contributor.authorHadjikakou, Sotiris K.
dc.date.accessioned2025-04-06T12:23:58Z
dc.date.available2025-04-06T12:23:58Z
dc.date.issued2025
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractIn this study, we report the synthesis, characterization, and biological investigation of antimony(III) halide complexes with various coordination architectures constructed from thiophene thiosemicarbazones. Antimony(III) thiophene-2-carbaldehyde thiosemicarbazone complexes (1, 2, 4, and 5) exhibit a square pyramidal geometry, with ligands coordinated to the central antimony atom in two distinct binding modes. In contrast, antimony(III) 2-acetylthiophene thiosemicarbazone complexes (3, 6, and 7) adopt a seesaw geometry. These complexes (1-7) represent the first reported examples of antimony(III) halide thiosemicarbazone compounds. The unique coordination environments observed in these complexes are of significant importance within the realm of antimony chemistry. These synthesized complexes exhibit different coordination geometries as well as potential biological activities. The antiproliferative activity against the human breast adenocarcinoma (MCF-7) cell line and antimicrobial activity against Gram-positive and Gram-negative bacteria were assessed. Antimony(III) thiophene-2-carbaldehyde thiosemicarbazone complexes (1, 2, 4, and 5) showed significant antiproliferative activity with IC50 values ranging from 8.5 to 19.1 mu M, while antimony(III) 2-acetylthiophene thiosemicarbazone complexes (3, 6, and 7) had higher IC50 values. Additionally, the antimony complexes demonstrated selective antimicrobial activity against Gram-negative bacteria.
dc.description.sponsorshipTekirdagbreve; Namimath;k Kemal UEniversitesi, Office of Scientific Research Projects [NKUBAP.01.DR.21.293]
dc.description.sponsorshipThis research was carried out in partial fulfillment of the requirements for the Ph.D. thesis of O.U. under the supervision ofyI.I.O. This research was promoted by the Tekirda & gbreve; Nam & imath;k Kemal UEniversitesi, Office of Scientific Research Projects (project no. NKUBAP.01.DR.21.293).
dc.identifier.doi10.1002/aoc.7858
dc.identifier.issn0268-2605
dc.identifier.issn1099-0739
dc.identifier.issue3
dc.identifier.scopus2-s2.0-85208052495
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1002/aoc.7858
dc.identifier.urihttps://hdl.handle.net/20.500.11776/17283
dc.identifier.volume39
dc.identifier.wosWOS:001344935100001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofApplied Organometallic Chemistry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250406
dc.subjectantimicrobial activity
dc.subjectantimony(III) complexes
dc.subjectantiproliferative activity
dc.subjectthiophene thiosemicarbazones
dc.subjectX-ray crystallography
dc.titleSynthesis, Characterization, and Biological Investigation of Antimony(III) Halide Complexes With Different Coordination Architectures Constructed From Thiophene Thiosemicarbazones
dc.typeArticle

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