Elucidating the Potential Side Effects of Current Anti-Seizure Drugs for Epilepsy

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dc.authorid0000-0002-3942-2097
dc.authorscopusid57200989999
dc.authorscopusid57222640358
dc.authorscopusid57226020899
dc.authorscopusid57220304990
dc.authorscopusid37034995600
dc.authorwosidAKYUZ, Enes/W-7801-2018
dc.contributor.authorAkyüz, Enes
dc.contributor.authorKöklü, Betül
dc.contributor.authorÖzenen, Cansu
dc.contributor.authorArulsamy, Alina
dc.contributor.authorShaikh, Mohd. Farooq
dc.date.accessioned2022-05-11T14:48:27Z
dc.date.available2022-05-11T14:48:27Z
dc.date.issued2021
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractOver the decades, various interventions have been developed and utilized to treat epilepsy. However, the majority of epileptic patients are often first prescribed anti-epileptic drugs (AED), now known as anti-seizure drugs (ASD), as the first line of defense to suppress their seizures and regain their quality of life. ASDs exert their anti-convulsant effects through various mechanisms of action, including regulation of ion channels, blocking glutamate-mediated stimulating neurotransmitter interaction, and enhancing the inhibitory GABA transmission. About one-third of epileptic patients are often resistant to anti-convulsant drugs, while others develop numerous side effects, which may lead to treatment discontinuation and further deterioration of quality of life. Common side effects of ASDs include headache, nausea and dizziness. However, more adverse effects, such as auditory and visual problems, skin problems, liver dysfunction, pancreatitis and kidney disorders may also be witnessed. Some ASDs may even result in life-threatening conditions as well as serious abnormalities, especially in patients with comorbidities and in pregnant women. Nevertheless, some clinicians had observed a reduction in the development of side effects post individualized ASD treatment. This suggests that a careful and well-informed ASD recommendation to patients may be crucial for an effective and side-effect-free control of their seizures. Therefore, this review aimed to elucidate the anticonvulsant effects of ASDs as well as their side effect profile by discussing their mechanism of action and reported adverse effects based on clinical and preclinical studies, thereby providing clinicians with a greater understanding of the safety of current ASDs.
dc.identifier.doi10.2174/1570159X19666210826125341
dc.identifier.endpage1883
dc.identifier.issn1570-159X
dc.identifier.issn1875-6190
dc.identifier.issue11en_US
dc.identifier.pmid34525933
dc.identifier.scopus2-s2.0-85122166715
dc.identifier.scopusqualityQ1
dc.identifier.startpage1865
dc.identifier.urihttps://doi.org/10.2174/1570159X19666210826125341
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10645
dc.identifier.volume19
dc.identifier.wosWOS:000720321300007
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorKöklü, Betül
dc.language.isoen
dc.publisherBentham Science Publ Ltd
dc.relation.ispartofCurrent Neuropharmacology
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAED
dc.subjectASD
dc.subjectpharmacological treatment
dc.subjectadverse effect
dc.subjectcomorbidity
dc.subjectanticonvulsant
dc.subjectAdverse Event Profile
dc.subjectAntiepileptic Drugs
dc.subjectValproic Acid
dc.subjectRodent Models
dc.subjectSafety
dc.subjectCarbamazepine
dc.subjectPhenytoin
dc.subjectChildren
dc.subjectOxcarbazepine
dc.subjectLamotrigine
dc.titleElucidating the Potential Side Effects of Current Anti-Seizure Drugs for Epilepsy
dc.typeReview Article

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