Predictive and prognostic impact of preoperative complete blood count based systemic inflammatory markers in testicular cancer

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dc.authorid0000-0002-5430-6561
dc.authorscopusid56641375200
dc.authorscopusid57215298496
dc.authorscopusid12754112600
dc.authorscopusid36151868000
dc.authorscopusid54885430100
dc.authorwosidArikan, Gurkan/AAO-7476-2021
dc.authorwosidArda, Ersan/L-7357-2016
dc.contributor.authorArda, Ersan
dc.contributor.authorArikan, Gurkan
dc.contributor.authorAkdere, Hakan
dc.contributor.authorAkgül, Murat
dc.contributor.authorYüksel, Ilkan
dc.date.accessioned2022-05-11T14:37:00Z
dc.date.available2022-05-11T14:37:00Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Üroloji Ana Bilim Dalı
dc.description.abstractPurpose: To determine the utility of preoperative complete blood count (CBC) based systemic inflammatory markers in the prediction of testicular cancer and its prognosis. Material and Methods: Between 2008-2017 the data of all testicular tumor patients undergoing radical orchiectomy were retrospectively analyzed. Patient baseseline characteristics (age, tumor stage, tumor markers, etc.) and results of routine preoperative blood tests including mean platelet volume (MPV), red cell distribution width (RDW), lymphocyte ratio (LR) and neutrophil ratio (NR) were retrieved. In addition, neutrophil to lymphocyte ratio (NLR) was calculated. Results: Mean age of the tumor and control group was 36.0 +/- 15 and 30.50 +/- 11 years, respectively. Mean RDW, NR and NLR were significantly higher in the tumor group with p values<0.001; whereas LR and MPV were significantly higher in the control group (p<0.001). Receiver Operating Characteristic (ROC) analyses of LR, NR, RDW, MPV, and NLR are shown in Table-3. The cut off values for RDW and NR were found as 13,7 (Area under the curve (AUC): 0.687, sensitivity = 42.2%, specificity = 84.8%) and 55.3 (AUC:0.693, sensitivity 72.2%, specificity 62%), respectively. Area under the curve for NLR in tumor group was 0.711, with a threshold value of 1.78 and sensitivity=81.8% and specificity= 55.4% (AUC:0.711/sig<0.001) that together with RDW exhibited the best differential diagnosis potential which could be used as an adjuvant tool in the prediction of testicular tumor and its prognosis. Conclusion: Several systemic inflammatory markers, which are obtained by routinely performed cost-effective blood tests, could demonstrate incremental predictive and prognostic information adjuvant to preoperativly achieved testiscular tumor markers.
dc.identifier.doi10.1590/S1677-5538.IBJU.2018.0820
dc.identifier.endpage223
dc.identifier.issn1677-5538
dc.identifier.issn1677-6119
dc.identifier.issue2en_US
dc.identifier.pmid32022510
dc.identifier.scopus2-s2.0-85078998795
dc.identifier.scopusqualityQ2
dc.identifier.startpage216
dc.identifier.urihttps://doi.org/10.1590/S1677-5538.IBJU.2018.0820
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8525
dc.identifier.volume46
dc.identifier.wosWOS:000530042300009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAkgül, Murat
dc.language.isoen
dc.publisherBrazilian Soc Urol
dc.relation.ispartofInternational Braz J Urol
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTesticular Neoplasms
dc.subjectNeutrophils
dc.subjectLymphocytes
dc.subjectTo-Lymphocyte Ratio
dc.subjectPretreatment Neutrophil
dc.subjectDiagnosis
dc.subjectAssociation
dc.subjectSurvival
dc.titlePredictive and prognostic impact of preoperative complete blood count based systemic inflammatory markers in testicular cancer
dc.typeArticle

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