Predictive value of hemogram parameters in malignant transformation of the endometrium in patients with different risk factors

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dc.contributor.authorFırat, Aysun
dc.contributor.authorErcan, Ayşegül
dc.contributor.authorMordeniz, Cengiz
dc.contributor.authorVerit Atmaca, Fatma Ferda
dc.date.accessioned2023-05-06T17:22:10Z
dc.date.available2023-05-06T17:22:10Z
dc.date.issued2023
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.description.abstractObjectivesTo investigate whether the pretreatment hemogram parameters and their ratios can be used in predicting the endometrial transformation in patients with abnormal uterine bleeding. Material and methodsRecords of all patients who underwent an endometrial histopathological evaluation between 2011 and 2021 were investigated. Hemogram, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) were analyzed. Chi square and Mann Whitney U tests were used for analysis. PResults427 patients were included, of whom 117 were presented with endometrial hyperplasia without atypia (27.4%; mean age, 42 +/- 9.7; Group II), 70 with atypia (16.3%; mean age, 53.4 +/- 9; Group III), 102 with early endometrial cancer (EC) (23.8%; mean age, 63 +/- 7.8; Group IV) and 38 with advanced disease (8.8%; mean age, 63.3 +/- 10.5; Group V). Patients without pathology constituted the control group (23.4%; mean age, 42.2 +/- 9.5; Group I). Risk factors for atypia and carcinoma were determined as age, postmenopausal state, obesity, diabetes, and increased estrogen exposure (each, p<0.05). There was no significant difference in NLR and PLR (p>0.05). However, hemoglobin and hematocrit levels were higher in Groups IV and V (13.9 vs 13.1 mg/dL, and 39.1 vs 38.8%, respectively; p<0.01). Platelet value was significantly higher in Groups III to V (282x10(9)/L, 283x10(9)/L and 295x10(9)/L; p<0.05, p<0.05 and p<0.01, respectively). ConclusionsOur findings support the impact of inflammation on malign transformation from normal endometrial mucosa to atypia and carcinoma. NLR and PLR values showed no statistical difference. Instead, thrombocytosis may have a predictive role in EC.
dc.identifier.doi10.1371/journal.pone.0279224
dc.identifier.issn1932-6203
dc.identifier.issue1en_US
dc.identifier.pmid36626395
dc.identifier.scopus2-s2.0-85146139902
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0279224
dc.identifier.urihttps://hdl.handle.net/20.500.11776/12086
dc.identifier.volume18
dc.identifier.wosWOS:000945435000001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorMordeniz, Cengiz
dc.language.isoen
dc.publisherPublic Library Science
dc.relation.ispartofPlos One
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNeutrophil-To-Lymphocyte
dc.subjectNeutrophil/Lymphocyte Ratio
dc.subjectPlatelet/Lymphocyte Ratio
dc.subjectPrognostic-Significance
dc.subjectCancer
dc.subjectInflammation
dc.subjectHyperplasia
dc.subjectErythropoietin
dc.subjectManagement
dc.subjectExpression
dc.titlePredictive value of hemogram parameters in malignant transformation of the endometrium in patients with different risk factors
dc.typeArticle

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