Investigation of the serum brain-derived neurotrophic factor in patients with alopecia areata: A preliminary study

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dc.authorscopusid27867662800
dc.authorscopusid29067508300
dc.authorscopusid56703436100
dc.authorscopusid26432848600
dc.authorscopusid36867089200
dc.authorscopusid10639223100
dc.authorscopusid55891056300
dc.contributor.authorErfan, Gamze
dc.contributor.authorAlbayrak, Yakup
dc.contributor.authorEmin Yanık, M.
dc.contributor.authorÜnsal, Cüneyt
dc.contributor.authorGünes, H.
dc.contributor.authorKulaç, Mustafa
dc.contributor.authorKuloğlu, Murat
dc.date.accessioned2022-05-11T14:10:17Z
dc.date.available2022-05-11T14:10:17Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Mikrobiyoloji Ana Bilim Dalı
dc.description.abstractObjectives: Alopecia areata (AA) is an asymptomatic hair loss; with mostly single, well-defined patches and in-group of non-scarring alopecia. There have been numerous studies that reported high percentages of psychiatric comorbidity in patients with alopecia areata. Beside these studies, to our knowledge there has been no study that researched a psychiatric biomarker such as brain-derived neurotrophic factor (BDNF) in first onset alopecia areata patients. Method: This study was conducted in Namık Kemal University Medical Faculty, Departments of Dermatology and Psychiatry between March 2013 and September 2014. After inclusion and exclusion criteria, 60 patients with first onset AA who have no current and past psychiatric disorder and 60 age-sex matched healthy subjects were compared in terms of serum brain-derived neurotrophic factor. Results: The age and female /male ratio were found to be insignificant between groups. The mean values of serum BDNF were 2.13±1.71 ng/dl and 2.32±1.93 ng/dl in AA group and in healthy control group respectively. The mean BDNF level was found to be similar between groups (t=2.76, p=0.61). Conclusions: According to our knowledge, this study is the first to compare serum BDNF between patients with first onset alopecia areata and healthy subjects. Our study might indicate that patients with alopecia areata have similar serum BDNF levels compared with normal population. Nonetheless, further studies are needed to support our preliminary results. © 2014, Istanbul Universitesi. All rights reserved.
dc.identifier.doi10.5455/NYS.20141024010909
dc.identifier.endpage16
dc.identifier.issn1300-8773
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84933500375
dc.identifier.scopusqualityN/A
dc.identifier.startpage12
dc.identifier.urihttps://doi.org/10.5455/NYS.20141024010909
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5350
dc.identifier.volume52
dc.indekslendigikaynakScopus
dc.institutionauthorErfan, Gamze
dc.institutionauthorAlbayrak, Yakup
dc.institutionauthorEmin Yanık, M.
dc.institutionauthorÜnsal, Cüneyt
dc.institutionauthorGünes, H.
dc.institutionauthorKulaç, Mustafa
dc.language.isotr
dc.publisherIstanbul Universitesi
dc.relation.ispartofYeni Symposium
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAlopecia
dc.subjectBDNF
dc.subjectBiomarker
dc.subjectbrain derived neurotrophic factor
dc.subjectalopecia areata
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectfemale
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectprotein blood level
dc.titleInvestigation of the serum brain-derived neurotrophic factor in patients with alopecia areata: A preliminary study
dc.title.alternativeAlopesi areata hastalarında beyin kaynaklı nörotrofik faktör (bdnf) düzeyleri: Bir ön çalışma]
dc.typeArticle

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