Aliphatic Polyester Nanofibers Functionalized with Cyclodextrins and Cyclodextrin-Guest Inclusion Complexes

Basit Öğe Kaydı
dc.authorid0000-0002-7762-2006
dc.authorid0000-0002-8692-4663
dc.authorid0000-0002-2716-7287
dc.authorscopusid56414474100
dc.authorscopusid55844637300
dc.authorscopusid56218275200
dc.authorscopusid7402195006
dc.authorscopusid35462778400
dc.authorwosidBoy, Ramiz/J-9923-2017
dc.contributor.authorNarayanan, Ganesh
dc.contributor.authorShen, Jialong
dc.contributor.authorBoy, Ramiz
dc.contributor.authorGupta, Bhupender S.
dc.contributor.authorTonelli, Alan E.
dc.date.accessioned2022-05-11T14:28:14Z
dc.date.available2022-05-11T14:28:14Z
dc.date.issued2018
dc.departmentFakülteler, Çorlu Mühendislik Fakültesi, Tekstil Mühendisliği Bölümü
dc.description.abstractThe fabrication of nanofibers by electrospinning has gained popularity in the past two decades; however, only in this decade, have polymeric nanofibers been functionalized using cyclodextrins (CDs) or their inclusion complexes (ICs). By combining electrospinning of polymers with free CDs, nanofibers can be fabricated that are capable of capturing small molecules, such as wound odors or environmental toxins in water and air. Likewise, combining polymers with cyclodextrin-inclusion complexes (CD-ICs), has shown promise in enhancing or controlling the delivery of small molecule guests, by minor tweaking in the technique utilized in fabricating these nanofibers, for example, by forming core-shell or multilayered structures and conventional electrospinning, for controlled and rapid delivery, respectively. In addition to small molecule delivery, the thermomechanical properties of the polymers can be significantly improved, as our group has shown recently, by adding non-stoichiometric inclusion complexes to the polymeric nanofibers. We recently reported and thoroughly characterized the fabrication of polypseudorotaxane (PpR) nanofibers without a polymeric carrier. These PpR nanofibers show unusual rheological and thermomechanical properties, even when the coverage of those polymer chains is relatively sparse (similar to 3%). A key advantage of these PpR nanofibers is the presence of relatively stable hydroxyl groups on the outer surface of the nanofibers, which can subsequently be taken advantage of for bioconjugation, making them suitable for biomedical applications. Although the number of studies in this area is limited, initial results suggest significant potential for bone tissue engineering, and with additional bioconjugation in other areas of tissue engineering. In addition, the behaviors and uses of aliphatic polyester nanofibers functionalized with CDs and CD-ICs are briefly described and summarized. Based on these observations, we attempt to draw conclusions for each of these combinations, and the relationships that exist between their presence and the functional behaviors of their nanofibers.
dc.identifier.doi10.3390/polym10040428
dc.identifier.issn2073-4360
dc.identifier.issue4en_US
dc.identifier.pmid30966463
dc.identifier.scopus2-s2.0-85045325894
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/polym10040428
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6720
dc.identifier.volume10
dc.identifier.wosWOS:000435087400086
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBoy, Ramiz
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofPolymers
dc.relation.publicationcategoryDiğeren_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectpoly(lactic acid)
dc.subjectpoly(epsilon-caprolactone)
dc.subjectcyclodextrins
dc.subjectcyclodextrin-inclusion complexes
dc.subjectcontrolled drug delivery
dc.subjectrapid dissolution
dc.subjectpseudorotaxanes
dc.subjectmechanical properties
dc.subjectBiodegradable Block-Copolymer
dc.subjectElectrospun Polylactic Acid
dc.subjectPoly Epsilon-Caprolactone
dc.subjectAlpha-Cyclodextrin
dc.subjectBeta-Cyclodextrin
dc.subjectBiodegradable/Bioabsorbable Polymers
dc.subjectCrystallization Behavior
dc.subjectMechanical-Properties
dc.subjectAntioxidant Activity
dc.subjectRelease Behavior
dc.titleAliphatic Polyester Nanofibers Functionalized with Cyclodextrins and Cyclodextrin-Guest Inclusion Complexes
dc.typeReview Article

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
6720.pdf
Boyut:
892.59 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Çorlu Mühendislik Fakültesi Koleksiyonu