Visfatin, Leptin, and TNF-alpha: Interrelated Adipokines in Insulin-Resistant Clinical and Subclinical Hypothyroidism

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dc.authorscopusid23968920100
dc.authorscopusid7003445991
dc.authorscopusid42661653300
dc.authorscopusid55635008600
dc.authorscopusid15727384300
dc.authorscopusid8713588200
dc.contributor.authorGüzel, Savaş
dc.contributor.authorSeven, Arzu
dc.contributor.authorGüzel, Eda Çelik
dc.contributor.authorBüyük, Banu
dc.contributor.authorÇelebi, Aslan
dc.contributor.authorAydemir, Birsen
dc.date.accessioned2022-05-11T14:12:34Z
dc.date.available2022-05-11T14:12:34Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalı
dc.description.abstractPurpose. This study is designed to evaluate the interrelationships among adipokines-visfatin, leptin, and tumor necrosis factor-alpha (TNF-alpha)- and insulin resistance (IR) in overt (n = 40) and subclinic hypothyroid (n = 25) patients and compare our findings with sex and body mass index-matched healthy controls (n = 25). Methods. Serum visfatin, leptin, and TNF-alpha levels were measured by enzyme-linked immunosorbent assay and C-reactive protein by immunoturbidimetry. Thyroid status (TSH, FT3, FT4) and lipid status (triglyceride, low-density lipoprotein-cholesterol, high-density lipoprotein-cholesterol, total cholesterol) parameters were measured. IR was determined by homeostatic model assessment (HOMA-IR) and McAuley (McA) indices. Results. HOMA-IR (p < 0.05) and McA indices (p < 0.01) revealed the presence of IR in overt hypothyroid patients. C-reactive protein, TNF-alpha, leptin, and visfatin levels were significantly higher (p < 0.01, p < 0.01, p < 0.001, and p < 0.001) in overt hypothyroid patients than euthyroid control group. Subclinic hypothyroid patients were observed to have significantly higher leptin and visfatin levels (p < 0.05) than euthyroid control group. In overt hypothyroid patients, we found plasma visfatin to be significantly positively correlated with HOMA-IR index (r = 0.336, p < 0.05) and body mass index (r = 0.445, p < 0.01) and negatively correlated with McA index (r = -0.574, p < 0.01). Conclusion. This study demonstrates the presence of IR in overt hypothyroid patients by HOMA and McA indices. Increased levels of visfatin, leptin, and TNF-alpha in overt and subclinic hypothyroid patients and the correlations among these adipokines highlighten their crucial role in the IR-associated disorders.
dc.identifier.doi10.3109/07435800.2012.760588
dc.identifier.endpage194
dc.identifier.issn0743-5800
dc.identifier.issn1532-4206
dc.identifier.issue3en_US
dc.identifier.pmid23324036
dc.identifier.scopus2-s2.0-84879512841
dc.identifier.scopusqualityQ2
dc.identifier.startpage184
dc.identifier.urihttps://doi.org/10.3109/07435800.2012.760588
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5602
dc.identifier.volume38
dc.identifier.wosWOS:000320867200007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüzel, Savaş
dc.institutionauthorGüzel, Eda Çelik
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofEndocrine Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectVisfatin
dc.subjectLeptin
dc.subjectAdipokines
dc.subjectInsulin resistant
dc.subjectHypothyroidism
dc.subjectType-2 Diabetes-Mellitus
dc.subjectColony-Enhancing Factor
dc.subjectAdiponectin Levels
dc.subjectImmune-Response
dc.subjectReference Range
dc.subjectAdipose-Tissue
dc.subjectVisceral Fat
dc.subjectGlucose
dc.subjectAssociation
dc.subjectSensitivity
dc.titleVisfatin, Leptin, and TNF-alpha: Interrelated Adipokines in Insulin-Resistant Clinical and Subclinical Hypothyroidism
dc.typeArticle

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