Factors Predicting Microinvasion in Ductal Carcinoma in situ

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dc.authorscopusid56037630800
dc.authorscopusid56037273500
dc.authorscopusid16687052800
dc.authorscopusid15045176000
dc.authorscopusid7003401660
dc.authorscopusid6602080155
dc.authorscopusid55913760200
dc.authorwosidCabıoğlu, Neslihan/AAZ-1196-2020
dc.authorwosidOzcinar, Beyza/AAF-3116-2020
dc.authorwosidOzmen, Vahit/AAE-3904-2020
dc.contributor.authorGürdal, Sibel Özkan
dc.contributor.authorCabıoğlu, Neslihan
dc.contributor.authorÖzçınar, Beyza
dc.contributor.authorMüslümanoğlu, Mahmut
dc.contributor.authorÖzmen, Vahit
dc.contributor.authorKeçer, Mustafa
dc.contributor.authorİğci, Abdullah
dc.date.accessioned2022-05-11T14:34:54Z
dc.date.available2022-05-11T14:34:54Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.description.abstractBackground: Whether sentinel lymph node biopsy (SLNB) should be performed in patients with pure ductal carcinoma in situ (DCIS) of the breast has been a question of debate over the last decade. The aim of this study was to identify factors associated with microinvasive disease and determine the criteria for performing SLNB in patients with DCIS. Materials and Methods: 125 patients with DCIS who underwent surgery between January 2000 and December 2008 were reviewed to identify factors associated with DCIS and DCIS with microinvasion (DCISM). Results: 88 patients (70.4%) had pure DCIS and 37 (29.6%) had DCISM. Among 33 DCIS patients who underwent SLNB, one patient (3.3%) was found to have isolated tumor cells in her biopsy, whereas 1 of 14 (37.8%) patients with DCISM had micrometastasis (7.1%). Similarly, of 16 patients (18.2%) with pure DCIS and axillary lymph node dissection (ALND) without SLNB, none had lymph node metastasis. Furthermore, of 20 patients with DCISM and ALND, only one (5%) had metastasis. In multivariate analysis, the presence of comedo necrosis [relative risk (RR)=4.1, 95% confidence interval (CI)=1.6-10.6, P=0.004], and hormone receptor (ER or PR) negativity (RR=4.0, 95% CI=1.5-11, P=0.007), were found to be significantly associated with microinvasion. Conclusions: Our findings suggest patients presenting with a preoperative diagnosis of DCIS associated with comedo necrosis or hormone receptor negativity are more likely to have a microinvasive component in definitive pathology following surgery, and should be considered for SLNB procedure along with patients who will undergo mastectomy due to DCIS.
dc.identifier.doi10.7314/APJCP.2014.15.1.55
dc.identifier.endpage60
dc.identifier.issn1513-7368
dc.identifier.issue1en_US
dc.identifier.pmid24528005
dc.identifier.scopus2-s2.0-84894083963
dc.identifier.scopusqualityQ3
dc.identifier.startpage55
dc.identifier.urihttps://doi.org/10.7314/APJCP.2014.15.1.55
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8134
dc.identifier.volume15
dc.identifier.wosWOS:000332001000011
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGürdal, Sibel Özkan
dc.language.isoen
dc.publisherAsian Pacific Organization Cancer Prevention
dc.relation.ispartofAsian Pacific Journal of Cancer Prevention
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDuctal carcinoma in situ
dc.subjectsentinel lymph node biopsy
dc.subjectmicroinvasion
dc.subjectLymph-Node Biopsy
dc.subjectInvasive Breast-Cancer
dc.subjectLocal Recurrence
dc.subjectSentinel
dc.subjectInsitu
dc.subjectRadiotherapy
dc.subjectMetastasis
dc.subjectPositivity
dc.subjectManagement
dc.subjectTamoxifen
dc.titleFactors Predicting Microinvasion in Ductal Carcinoma in situ
dc.typeArticle

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