Osteoprotegerin, leptin and IL-6: Association with silent myocardial ischemia in type 2 diabetes mellitus

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dc.authorscopusid23968920100
dc.authorscopusid7003445991
dc.authorscopusid55543290400
dc.authorscopusid55543253700
dc.authorscopusid42661653300
dc.authorscopusid27968034900
dc.authorscopusid15727384300
dc.contributor.authorGüzel, Savaş
dc.contributor.authorSeven, Arzu
dc.contributor.authorKocaoglu, Ali
dc.contributor.authorİlk, Banu
dc.contributor.authorGüzel, Eda Çelik
dc.contributor.authorSaraçoğlu Varol, Gamze
dc.contributor.authorÇelebi, Asian
dc.date.accessioned2022-05-11T14:12:34Z
dc.date.available2022-05-11T14:12:34Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Aile Hekimliği Ana Bilim Dalı
dc.description.abstractBackground: Diabetic patients often exhibit severe, asymptomatic coronary artery disease (CAD). The relationship between osteoprotegerin (OPG), inflammatory markers and silent myocardial ischemia remains to be elucidated. Methods: We recruited 45 type 2 diabetic patients and 33 healthy controls and assessed them for silent myocardial ischemia (SMI) by myocardial perfusion imaging. Patient blood was tested for OPG, IL-6 and leptin concentrations. Results: OPG, leptin and IL-6 levels were found significantly elevated in diabetic patients (p < 0.001, p < 0.01, p < 0.05). Based on our classification of presence/absence of SMI in our diabetic group, we found that there was a significant association between SMI and the biomarkers IL-6 (p <0.001), leptin (p<0.001) and OPG (p <0.05). In multivariate regression analyses, OPG was found to be significantly related to diabetes mellitus and to SMI. Age, sex and smoking increased the association between OPG and SMI. Conclusion: High OPG, leptin and IL-6 levels are associated with the presence and severity of SMI in type 2 diabetic patients.
dc.identifier.doi10.1177/1479164112440815
dc.identifier.endpage31
dc.identifier.issn1479-1641
dc.identifier.issn1752-8984
dc.identifier.issue1en_US
dc.identifier.pmid22496403
dc.identifier.scopus2-s2.0-84871827823
dc.identifier.scopusqualityQ2
dc.identifier.startpage25
dc.identifier.urihttps://doi.org/10.1177/1479164112440815
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5601
dc.identifier.volume10
dc.identifier.wosWOS:000314327900004
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGüzel, Savaş
dc.institutionauthorSeven, Arzu
dc.institutionauthorKocaoglu, Ali
dc.institutionauthorİlk, Banu
dc.institutionauthorGüzel, Eda Çelik
dc.institutionauthorSaraçoğlu Varol, Gamze
dc.institutionauthorÇelebi, Asian
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.ispartofDiabetes & Vascular Disease Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDiabetes mellitus
dc.subjecttype 2 diabetes
dc.subjectIL-6
dc.subjectleptin
dc.subjectmyocardial ischemia
dc.subjectosteoprotegerin
dc.subjectcoronary artery disease
dc.subjectCoronary-Artery Calcification
dc.subjectPlasma Osteoprotegerin
dc.subjectCirculating Osteoprotegerin
dc.subjectInsulin Sensitivity
dc.subjectDisease
dc.subjectRisk
dc.subjectMicroalbuminuria
dc.subjectAtherosclerosis
dc.subjectHypertension
dc.subjectPrevalence
dc.titleOsteoprotegerin, leptin and IL-6: Association with silent myocardial ischemia in type 2 diabetes mellitus
dc.typeArticle

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