Reduced total antioxidant level and increased oxidative stress in patients with deficit schizophrenia: A preliminary study

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dc.authorid0000-0002-8612-528X
dc.authorid0000-0002-5770-344X
dc.authorscopusid29067508300
dc.authorscopusid26432848600
dc.authorscopusid27967486000
dc.authorscopusid55416074700
dc.authorscopusid55891056300
dc.authorwosidBEYAZYUZ, MURAT/ABA-7934-2020
dc.authorwosidÜnal, Ahmet/ABH-9455-2020
dc.authorwosidAlbayrak, Yakup/ABA-7651-2020
dc.contributor.authorAlbayrak, Yakup
dc.contributor.authorÜnsal, Cüneyt
dc.contributor.authorBeyazyüz, Murat
dc.contributor.authorÜnal, Ahmet
dc.contributor.authorKuloğlu, Murat
dc.date.accessioned2022-05-11T14:41:04Z
dc.date.available2022-05-11T14:41:04Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Ruh Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractIntroduction: Deficit schizophrenia (DS) is defined for identifying a relatively homogeneous subgroup of patients with diagnosis of schizophrenia, characterized by the presence of primary and enduring negative symptoms. There have been several studies which investigated the status of oxidative stress and total antioxidant level in patients with schizophrenia. However, there is not any study which researched differences between DS and nondeficit schizophrenia (NDS) in terms of status of oxidative stress and antioxidant level. We hypothesized that patients with DS would have different status of oxidative stress and antioxidant levels compared with patients with NDS. Methods: Twenty-three patients with DS, 42 patients with NDS and 31 age, sex and smoking status matched healthy controls (HC) were included to study. Five milliliters of blood was drawn from control subjects and patients for assessing total antioxidant potential (TAOP) and total peroxide levels (TPEROX). The ratio of TPEROX to TAOP is referred as oxidative stress index (OSI). Results: We noticed that serum TAOP level was significantly lower in DS group compared with NDS and HC groups. The OSI was also found to be higher in DS group compared with NDS and HC groups. Furthermore, serum TAOP level and status of OSI were similar between NDS and HC groups. Conclusion: Our study is the first to demonstrate differences between DS and NDS in terms of status of oxidative stress and serum total antioxidant level. We suggest that our study represents novel and important results in terms of supporting provides and hypothesis which considered DS as a different disease entity with respect to NDS. Further studies are needed for investigating the status of antioxidants and oxidative stress and their clinical implications in deficit schizophrenia. (C) 2013 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.pnpbp.2013.04.020
dc.identifier.endpage149
dc.identifier.issn0278-5846
dc.identifier.issn1878-4216
dc.identifier.pmid23657077
dc.identifier.scopus2-s2.0-84878851248
dc.identifier.scopusqualityQ1
dc.identifier.startpage144
dc.identifier.urihttps://doi.org/10.1016/j.pnpbp.2013.04.020
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9047
dc.identifier.volume45
dc.identifier.wosWOS:000323238300019
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÜnsal, Cüneyt
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofProgress in Neuro-Psychopharmacology & Biological Psychiatry
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntioxidant
dc.subjectDeficit schizophrenia
dc.subjectOxidative stress
dc.subjectPlacebo-Controlled Trial
dc.subjectLipid-Peroxidation
dc.subjectSuperoxide-Dismutase
dc.subjectGinkgo-Biloba
dc.subjectEnzyme Levels
dc.subjectDefense System
dc.subjectFatty-Acids
dc.subjectVitamin-E
dc.subjectHaloperidol
dc.subjectBrain
dc.titleReduced total antioxidant level and increased oxidative stress in patients with deficit schizophrenia: A preliminary study
dc.typeArticle

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