In Vitro Evaluation of Electrospun Polysaccharide Based Nanofibrous Mats as Surgical Adhesion Barriers

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dc.authorid0000-0003-3673-1940
dc.authorid0000-0002-3595-6286
dc.authorid0000-0002-7687-3284
dc.authorscopusid55292814400
dc.authorscopusid16235098100
dc.authorscopusid26533892300
dc.authorscopusid17344029200
dc.authorwosidSAFAK, Serife/AAB-4034-2020
dc.authorwosidCinkilic, Nilufer/AAH-5296-2021
dc.authorwosidVATAN, Ozgur/O-7508-2015
dc.contributor.authorŞafak, Şerife
dc.contributor.authorVatan, Özgür
dc.contributor.authorÇinkılıç, Nilüfer
dc.contributor.authorKaraca, Esra
dc.date.accessioned2022-05-11T14:28:17Z
dc.date.available2022-05-11T14:28:17Z
dc.date.issued2020
dc.departmentFakülteler, Çorlu Mühendislik Fakültesi, Tekstil Mühendisliği Bölümü
dc.description.abstractPost-operative adhesions are one of the most important problems faced by patients and surgeons. In this study, nanofibrous mats were produced as novel surgical adhesion barrier from polysaccharide-based polymers, hyaluronic acid, carboxymethyl cellulose and sodium alginate, via electrospinning. The produced nanofibrous mats were crosslinked with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride and N-hydroxysulfosuccinimide. Furthermore, the morphology, in vitro degradation, cytotoxicity and cell adherence potentials of the nanofibrous mats aimed to be used as adhesion barriers were evaluated and compared with a commercial adhesion barrier. Results of the in vitro experiment showed that the nanofibrous mats have maintained their physical structures during the critical period for adhesion formation, and had non-adherent cell feature and non-cytotoxic nature required for an ideal adhesion barrier.
dc.description.sponsorshipTUBITAK (The Scientific and Technical Research Council of Turkey)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [214M415]
dc.description.sponsorshipThe authors thank to TUBITAK (The Scientific and Technical Research Council of Turkey) for its financial support in the research project (No. 214M415).
dc.identifier.doi10.32710/tekstilvekonfeksiyon.548460
dc.identifier.endpage107
dc.identifier.issn1300-3356
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85095881228
dc.identifier.scopusqualityQ3
dc.identifier.startpage99
dc.identifier.urihttps://doi.org/10.32710/tekstilvekonfeksiyon.548460
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6749
dc.identifier.volume30
dc.identifier.wosWOS:000576363800003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorŞafak, Şerife
dc.language.isoen
dc.publisherEge Univ
dc.relation.ispartofTekstil Ve Konfeksiyon
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNanofiber
dc.subjectadhesion barrier
dc.subjectpolysaccharide polymers
dc.subjectin vitro
dc.subjectHyaluronic-Acid
dc.subjectPrevention
dc.subjectMembranes
dc.subjectHydrogels
dc.subjectDelivery
dc.titleIn Vitro Evaluation of Electrospun Polysaccharide Based Nanofibrous Mats as Surgical Adhesion Barriers
dc.typeArticle

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