Protective Effect of Curcumin on Carbapenem-Resistant Escherichia coli-Induced Lung Injury in Rats

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dc.authorid0000-0002-1161-3369
dc.authorid0000-0002-4419-5693
dc.authorid0000-0003-0268-8999
dc.authorid0000-0001-5845-699X
dc.authorid0000-0003-2615-1918
dc.authorid0000-0002-2481-0978
dc.authorscopusid56043199900
dc.authorscopusid54892706700
dc.authorscopusid36961208100
dc.authorscopusid17134802600
dc.authorscopusid23479036200
dc.authorscopusid7004359268
dc.authorscopusid16318360400
dc.authorwosidyabanoglu, hakan/AAJ-7865-2021
dc.authorwosidÖzmete, Özlem/AAI-7779-2021
dc.authorwosidBali, Çağla/AAI-8790-2021
dc.authorwosidaribogan, anis/S-8336-2019
dc.authorwosidNoyan, Mustafa Turgut/AAK-2011-2021
dc.authorwosidAltinsoy, Bulent/A-9666-2017
dc.contributor.authorBali, Cagla
dc.contributor.authorAltıntaş, Nejat
dc.contributor.authorÖzmete, Özlem
dc.contributor.authorGelincik, İbrahim
dc.contributor.authorYabanoglu, Hakan
dc.contributor.authorTekin, Neslihan
dc.contributor.authorAribogan, Anis
dc.date.accessioned2022-05-11T14:09:59Z
dc.date.available2022-05-11T14:09:59Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Göğüs Cerrahisi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Anesteziyoloji ve Reanimasyon Ana Bilim Dalı
dc.description.abstractCurcumin has remarkable anti-inflammatory and antioxidant properties. The aim of this study was to investigate the protective effects of curcumin on a rat model of carbapenemresistant Escherichia coli-induced acute lung injury (ALI). Thirty-two rats were randomly allocated to 4 groups to induce an ALI: negative control group (rats not infected with E coli with no antibiotic treatment), positive control group (rats infected with E coli with no antibiotic treatment), imipenem group (rats infected with E coli that received intraperitoneal injection of imipenem), and the imipenem+curcumin group (rats infected with E coli that received intraperitoneal injection of imipenem and were fed on curcumin). The rats were killed, and lung tissues samples were harvested for biochemical analyses and histopathologic examination. Total antioxidant status (TAS), total oxidant status (TOS), tumor necrosis factor alpha (TNF alpha), and interleukin-6 (IL6) were measured. TOS increased in the positive control group (P < 0.001) and decreased in the imipenem and imipenem+curcumin groups (P < 0.001 and P < 0.001, respectively). TAS decreased in the positive control group (P = 0.005). Imipenem treatment did not increase TAS, but the imipenem+curcumin group increased TAS (P = 0.014). TNF alpha and IL6 increased in the positive control group compared with the negative control group (P < 0.001 and P = 0.010, respectively). Imipenem decreased TNF alpha (P < 0.001), but did not decrease IL6 (P = 0.418). Imipenem+curcumin decreased TNF alpha (P < 0.001); this decrease was more pronounced compared with the imipenem group (P = 0.008). IL6 decreased in the curcumin group compared with the positive control group (P = 0.011). Curcumin combined with imipenem can be an alternative therapeutic agent to overcome the resistance of E coli strains.
dc.description.sponsorshipBaskent UniversityBaskent University [DA 15/05]
dc.description.sponsorshipThis study was supported by the Baskent University Research Fund (Project DA 15/05).
dc.identifier.doi10.9738/INTSURG-D-15-00256.1
dc.identifier.endpage312
dc.identifier.issn0020-8868
dc.identifier.issue45511en_US
dc.identifier.scopus2-s2.0-85025164380
dc.identifier.scopusqualityQ4
dc.identifier.startpage304
dc.identifier.urihttps://doi.org/10.9738/INTSURG-D-15-00256.1
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5235
dc.identifier.volume101
dc.identifier.wosWOS:000406051800002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAltıntaş, Nejat
dc.institutionauthorGelincik, İbrahim
dc.language.isoen
dc.publisherInt College Of Surgeons
dc.relation.ispartofInternational Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCurcumin
dc.subjectCarbapenem-resistant E coli
dc.subjectAcute lung injury
dc.subjectRespiratory-Distress-Syndrome
dc.subjectStaphylococcus-Aureus
dc.subjectInflammation
dc.subjectInfection
dc.subjectEnterobacteriaceae
dc.subjectEpidemiology
dc.subjectAntioxidant
dc.subjectModels
dc.subjectMice
dc.titleProtective Effect of Curcumin on Carbapenem-Resistant Escherichia coli-Induced Lung Injury in Rats
dc.typeArticle

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