The outcome of COVID-19 in patients with hematological malignancy

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dc.authorid0000-0003-4304-9245
dc.authorid0000-0002-3285-417X
dc.authorid0000-0003-1864-0316
dc.authorid0000-0001-9962-8882
dc.authorid0000-0003-2131-2866
dc.authorid0000-0003-0825-1851
dc.authorscopusid57189243089
dc.authorscopusid24471549000
dc.authorscopusid6602557128
dc.authorscopusid56545735000
dc.authorscopusid56370690600
dc.authorscopusid14022986200
dc.authorscopusid55672209100
dc.authorwosidHacıbekiroğlu, Tuba/ABH-2380-2020
dc.authorwosidBaşcı, Semih/AAB-4823-2021
dc.authorwosidBasturk, Abdulkadir/B-1962-2018
dc.authorwosidErkurt, Mehmet Ali/ABI-7232-2020
dc.authorwosidYigenoglu, Tugce/ABF-6595-2021
dc.contributor.authorYigenoğlu, Tuğçe Nur
dc.contributor.authorAta, Naim
dc.contributor.authorAltuntaş, Fevzi
dc.contributor.authorBaşçı, Semih
dc.contributor.authorDal, Mehmet Sinan
dc.contributor.authorKorkmaz, Serdal
dc.contributor.authorBirinci, Şuayip
dc.contributor.authorTurgut, Burhan
dc.date.accessioned2022-05-11T14:40:02Z
dc.date.available2022-05-11T14:40:02Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.description.abstractIn this study, we aim to report the outcomes for COVID-19 in patients with hematological malignancy in Turkey. Data from laboratory-confirmed 188 897 COVID-19 patients diagnosed between 11 March 2020 and 22 June 2020 included in the Republic of Turkey, Ministry of Health database were analyzed retrospectively. All COVID-19 patients with hematological malignancy (n = 740) were included in the study and an age, sex, and comorbidity-matched cohort of COVID-19 patients without cancer (n = 740) at a 1:1 ratio was used for comparison. Non-Hodgkin lymphoma (30.1%), myelodysplastic syndrome (19.7%), myeloproliferative neoplasm (15.7%) were the most common hematological malignancies. The rates of severe and critical disease were significantly higher in patients with hematological malignancy compared with patients without cancer (P = .001). The rates of hospital and intensive care unit (ICU) admission were higher in patients with hematological malignancy compared with the patients without cancer (P = .023,P = .001, respectively). The length of hospital stay and ICU stay was similar between groups (P = .7,P = .3, retrospectively). The rate of mechanical ventilation (MV) support was higher in patients with hematological malignancy compared with the control group (P = .001). The case fatality rate was 13.8% in patients with hematological malignancy, and it was 6.8% in the control group (P = .001). This study reveals that there is an increased risk of COVID-19-related serious events (ICU admission, MV support, or death) in patients with hematological malignancy compared with COVID-19 patients without cancer and confirms the high vulnerability of patients with hematological malignancy in the current pandemic.
dc.identifier.doi10.1002/jmv.26404
dc.identifier.endpage1104
dc.identifier.issn0146-6615
dc.identifier.issn1096-9071
dc.identifier.issue2en_US
dc.identifier.pmid32776581
dc.identifier.scopus2-s2.0-85089856598
dc.identifier.scopusqualityQ1
dc.identifier.startpage1099
dc.identifier.urihttps://doi.org/10.1002/jmv.26404
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8842
dc.identifier.volume93
dc.identifier.wosWOS:000562502800001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTurgut, Burhan
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofJournal of Medical Virology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCOVID-19
dc.subjecthematological malignancy
dc.subjectSARS-CoV-2
dc.titleThe outcome of COVID-19 in patients with hematological malignancy
dc.typeArticle

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