Thymoquinone Ameliorates Cadmium-Induced Nephrotoxicity, Apoptosis, and Oxidative Stress in Rats is Based on its Anti-Apoptotic and Anti-Oxidant Properties

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dc.authorscopusid36023238400
dc.authorscopusid7006356462
dc.authorscopusid24436194200
dc.authorscopusid55515412500
dc.authorscopusid56659422100
dc.authorscopusid56755425900
dc.authorscopusid36866111300
dc.authorwosidsener, umit/AAZ-7728-2020
dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorErboğa, Mustafa
dc.contributor.authorKanter, Mehmet
dc.contributor.authorAktaş, Cevat
dc.contributor.authorŞener, Ümit
dc.contributor.authorErboğa, Zeynep Fidanol
dc.contributor.authorDönmez, Yeliz Bozdemir
dc.contributor.authorGürel, Ahmet
dc.date.accessioned2022-05-11T14:10:16Z
dc.date.available2022-05-11T14:10:16Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Fizyoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractCadmium (Cd), an environmental and industrial pollutant, generates free radicals responsible for oxidative stress. Cd can also lead to various renal toxic damage such as the proximal tubules and glomerulus dysfunction. Thymoquinone (TQ) is the main constituent of the essential oil obtained from black seeds (Nigella sativa) and has various pharmacological effects. The aim of the present study was to examine the nephroprotective, anti-oxidant, and anti-apoptotic effect of the TQ against Cd-induced nephrotoxicity. A total of 24 male Wistar albino rats were divided into three groups: control, Cd-treated, and Cd-treated with TQ; each group contain eight animals. The Cd-treated group was injected subcutaneously with CdCl2 dissolved in saline in the amount of 2 ml/kg/day for 30 days, resulting in a dosage of 1 mg/kg Cd. The rats in TQ-treated groups were given TQ (50 mg/kg body weight) once a day orally together with first Cd injection during the study period. The histopathological studies in the kidney of rats also showed that TQ markedly reduced the toxicity of Cd and preserved the normal histological architecture of the renal tissue. Immunohistochemical analysis revealed that TQ significantly decreased the Cd-induced over expression of nuclear factor-kappa B in renal tissue. Furthermore, TQ treatment resulted in decreased the number of apoptotic cells. TQ significantly suppressed lipid peroxidation, compensated deficits in the anti-oxidant defenses (reduced superoxide dismutase, glutathione peroxidase and catalase activities) in renal tissue resulted from Cd administration. These findings suggest that the nephroprotective potential of TQ in Cd toxicity might be due to its anti-oxidant and anti-apoptotic properties, which could be useful for achieving optimum effects in Cd-induced nephrotoxicity.
dc.identifier.doi10.1007/s12011-015-0453-x
dc.identifier.endpage172
dc.identifier.issn0163-4984
dc.identifier.issn1559-0720
dc.identifier.issue1en_US
dc.identifier.pmid26226832
dc.identifier.scopus2-s2.0-84957440516
dc.identifier.scopusqualityQ1
dc.identifier.startpage165
dc.identifier.urihttps://doi.org/10.1007/s12011-015-0453-x
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5348
dc.identifier.volume170
dc.identifier.wosWOS:000369941500019
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorErboğa, Mustafa
dc.institutionauthorAktaş, Cevat
dc.institutionauthorŞener, Ümit
dc.institutionauthorErboğa, Zeynep Fidanol
dc.institutionauthorDönmez, Yeliz Bozdemir
dc.institutionauthorGürel, Ahmet
dc.language.isoen
dc.publisherHumana Press Inc
dc.relation.ispartofBiological Trace Element Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCadmium
dc.subjectThymoquinone
dc.subjectNephrotoxicity
dc.subjectApoptosis
dc.subjectRats
dc.subjectNigella-Sativa
dc.subjectRenal Toxicity
dc.subjectKidney
dc.subjectInjury
dc.subjectDamage
dc.subjectConstituent
dc.subjectMechanisms
dc.subjectCisplatin
dc.subjectSelenium
dc.subjectCells
dc.titleThymoquinone Ameliorates Cadmium-Induced Nephrotoxicity, Apoptosis, and Oxidative Stress in Rats is Based on its Anti-Apoptotic and Anti-Oxidant Properties
dc.typeArticle

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