Serum Endocan Levels in Children with Community-Acquired Pneumonia

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dc.authorid0000-0003-3587-6830
dc.authorscopusid36161405300
dc.authorscopusid55213882800
dc.authorscopusid57194590593
dc.authorscopusid56577980100
dc.authorscopusid23968920100
dc.authorwosidPaketci, Cem/A-1490-2018
dc.authorwosidERDEDE, ÖZLEM/ABC-1973-2021
dc.contributor.authorPaketçi, Cem
dc.contributor.authorPaketçi, Ahu
dc.contributor.authorErdede, Özlem
dc.contributor.authorDemirkol, Muhammet
dc.contributor.authorGüzel, Savaş
dc.date.accessioned2022-05-11T14:14:02Z
dc.date.available2022-05-11T14:14:02Z
dc.date.issued2017
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractIn this study, it was aimed to compare the levels of serum endocan with commonly used markers, and also to define the suitability for determination of disease severity in patients with community-acquired pneumonia (CAP). The study included 60 patients and 28 healthy subjects. Pneumonia severity was determined according to British Thoracic Society guidelines for the management of CAP in children. Serum levels of endocan and C-reactive protein (CRP) and white blood cell (WBC), and neutrophil count were measured. Serum endocan levels were increased in patients with CAP. CRP levels, WBC count, neutrophil count and neutrophil lymphocyte ratio were also higher in the CAP group than healthy control group. Endocan was correlated with CRP and WBC count and disease severity. For the identification of CAP, the area under the receiver operating characteristic (ROC) curve of CRP was acceptable for CRP, but not for endocan (0.812 and 0.649, respectively). ROC analysis for endocan to differentiate between severe CAP (n = 29) and mild-moderate CAP (n = 31) gave an area under the curve of 0.769 compared to 0.667 for CRP. Serum endocan levels increase in patients with CAP and can therefore be a useful marker in diagnosis and as a particular indicator of the treatment in the clinical assessment of CAP disease severity. Serum endocan levels of patients with severe CAP were higher compared with patients with mild-moderate CAP. These results revealed that endocan might be a useful indicator of severity of CAP.
dc.identifier.doi10.1089/ped.2017.0744
dc.identifier.endpage85
dc.identifier.issn2151-321X
dc.identifier.issn2151-3228
dc.identifier.issue2en_US
dc.identifier.scopus2-s2.0-85021124390
dc.identifier.scopusqualityQ3
dc.identifier.startpage80
dc.identifier.urihttps://doi.org/10.1089/ped.2017.0744
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5757
dc.identifier.volume30
dc.identifier.wosWOS:000405557800004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorPaketçi, Cem
dc.institutionauthorErdede, Özlem
dc.institutionauthorDemirkol, Muhammet
dc.institutionauthorGüzel, Savaş
dc.language.isoen
dc.publisherMary Ann Liebert, Inc
dc.relation.ispartofPediatric Allergy Immunology and Pulmonology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectbiomarker
dc.subjectendocan
dc.subjectendothelial cell-specific molecule-1
dc.subjectinflammation
dc.subjectpneumonia
dc.subjectCell-Specific Molecule-1
dc.subjectSepsis
dc.subjectBiomarker
dc.subjectDisease
dc.subjectMarker
dc.titleSerum Endocan Levels in Children with Community-Acquired Pneumonia
dc.typeArticle

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