Epidemiology and prognosis of sepsis in cancer patients: A multicenter prospective observational study

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dc.contributor.authorTure, Zeynep
dc.contributor.authorİskender, Gülşen
dc.contributor.authorSerhat Şahinoğlu, Mustafa
dc.contributor.authorBeste Özkara, Ezel
dc.contributor.authorKalem, Ayşe Kaya
dc.contributor.authorEryılmaz Eren, Esma
dc.contributor.authorÜrkmez, Fatma Yekta
dc.date.accessioned2025-04-06T12:21:56Z
dc.date.available2025-04-06T12:21:56Z
dc.date.issued2025
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractObjectives: To determine the epidemiology and prognosis of sepsis in cancer patients and the influence of sepsis on the mortality of cancer patients. Methods: In this multicenter, prospective, observational study, cancer patients hospitalized without sepsis followed up until discharge or a maximum of 90 days were included. The incidence of sepsis in the follow-up period, risk factors for sepsis, risk factors for 28-day mortality in patients with sepsis and 90-day mortality in the entire group were determined. Results: During the study, 790 cancer patients were included. Sepsis developed in 72 patients (9.1 %) during the follow-up. Older age, hospitalization due to any infection, graft versus host diseases (GVHD), the presence of a urethral catheter, and previous bacterial infection in the last three months were risk factors of sepsis. Among all cancer patients, sepsis was found to be the most important factor influencing 90-day mortality (OR 13.42(1.79–6.83)). Mortality among the sepsis cohort was independently associated with an infection with a carbapenem-resistant bacterium (OR 15.47(1.45–64.17)), appropriateness of empirical treatment (OR 5.02 (0.17–7.61) and having a clinical improvement on the fifth day of the treatment (OR 10.58(0.39–28.25). Conclusions: Sepsis was documented in one out of 11 hospitalized cancer patients and the mortality rate increases 13-fold when sepsis develops. Invasive devices, GVHD, and previous bacterial infections were related to sepsis and antibiotic resistance were the most important driver for mortality. Antimicrobial stewardship, rational use of catheters (if necessary, in accordance with asepsis/antisepsis, short-term use) is important to save lives in cancer patients. © 2025
dc.identifier.doi10.1016/j.amjms.2025.02.008
dc.identifier.issn0002-9629
dc.identifier.pmid39952291
dc.identifier.scopus2-s2.0-105000024870
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.amjms.2025.02.008
dc.identifier.urihttps://hdl.handle.net/20.500.11776/17017
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherElsevier B.V.
dc.relation.ispartofAmerican Journal of the Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20250406
dc.subjectAntimicrobial resistance
dc.subjectCancer
dc.subjectMalignancy
dc.subjectMortality
dc.subjectRisk factor
dc.subjectSepsis
dc.subjectUrinary catheter
dc.titleEpidemiology and prognosis of sepsis in cancer patients: A multicenter prospective observational study
dc.typeArticle

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