Effects of jnk inhibitor on inflammation and fibrosis in the ovary tissue of a rat model of polycystic ovary syndrome

Basit Öğe Kaydı
dc.authorid0000-0001-5191-1072
dc.authorid0000-0002-5344-9739
dc.authorid0000-0001-7775-5792
dc.authorscopusid26646261000
dc.authorscopusid14622889300
dc.authorscopusid55134339900
dc.authorscopusid24461835200
dc.authorscopusid24461417500
dc.authorwosidKurdoglu, Zehra/A-2453-2019
dc.authorwosidKurdoglu, Mertihan/J-5462-2017
dc.authorwosidErten, Remzi/V-5175-2019
dc.contributor.authorBulut, Gülay
dc.contributor.authorKurdoğlu, Zehra
dc.contributor.authorDönmez, Yeliz Bozdemir
dc.contributor.authorKurdoğlu, Mertihan
dc.contributor.authorErten, Remzi
dc.date.accessioned2022-05-11T14:41:28Z
dc.date.available2022-05-11T14:41:28Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractObjective: In our study, we aimed to investigate the effects of Jun N-terminal kinase inhibitor (SP600125) on fibrosis and inflammation in rats with polycystic ovary syndrome (PCOS). Method: 50 Wistar-albino rats were divided into five groups (n=10 each): control group, sham group, PCOS group, SP600125+ PCOS group and SP600125 group. In the estradiol valerate (EV)-treated group in which PCOS was injected with a single 4 mg/kg i.p. of EV in 0.2 ml sesame oil and the rats were sacrificed on day 60. The estradiol valerate (EV)-treated + SP600125-treated group was injected with a single 4 mg/kg i.p. of EV in 0.2 ml sesame oil. As of day 60, the treatment group was additionally given 15 mg/kg i.p. of SP600125 once daily for 4 consecutive days and the rats were sacrificed on day 65. Histopathological findings (ovarian morphology, edema, inflammatory cell infiltration, vascular congestion and hyperemia) and collagen type IV immunoexpression were assessed. Results: The SP600125+ PCOS group showed a significant level of improvement in ovarian follicle morphology, edema, inflammatory infiltrate, vascular congestion and hyperemia as compared with the PCOS group. Furthermore, collagen type IV immunoexpression showed a significant reduction in staining intensity on the theca cell layer and ovary stroma as compared to the PCOS group. Conclusion: This study demonstrates the therapeutic effect of SP600125 in the prevention of PCOS in an experimental model.
dc.description.sponsorshipYuzuncu Yil University Scientific Research Project Coordination Unit, Van, TurkeyYuzuncu Yil University [2014-HIZ-TF079]
dc.description.sponsorshipThis project is supported by a Grant from Yuzuncu Yil University Scientific Research Project Coordination Unit, Van, Turkey. (2014-HIZ-TF079).
dc.identifier.endpage8785
dc.identifier.issn1936-2625
dc.identifier.issue8en_US
dc.identifier.pmid26464620
dc.identifier.scopus2-s2.0-84962584125
dc.identifier.scopusqualityN/A
dc.identifier.startpage8774
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9187
dc.identifier.volume8
dc.identifier.wosWOS:000364775400007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDönmez, Yeliz Bozdemir
dc.language.isoen
dc.publisherE-Century Publishing Corp
dc.relation.ispartofInternational Journal of Clinical and Experimental Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFibrosis
dc.subjectinflammation
dc.subjectJun N-terminal kinase inhibitor
dc.subjectpolycystic ovary syndrome
dc.subjectGrowth-Factor-Beta
dc.subjectActivated Protein-Kinase
dc.subjectN-Terminal Kinase
dc.subjectGrade Chronic Inflammation
dc.subjectNecrosis-Factor-Alpha
dc.subjectC-Jun
dc.subjectInsulin-Resistance
dc.subjectSignaling Pathways
dc.subjectApoptosis
dc.subjectCells
dc.titleEffects of jnk inhibitor on inflammation and fibrosis in the ovary tissue of a rat model of polycystic ovary syndrome
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
9187.pdf
Boyut:
3.68 MB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu