Immunohistochemical investigation of caspase-3 in neuronal apoptosis after experimental closed head trauma

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dc.authorscopusid24436194200
dc.authorscopusid7006356462
dc.authorscopusid55135463200
dc.authorscopusid55135930200
dc.contributor.authorAktaş, Cevat
dc.contributor.authorKanter, Mehmet
dc.contributor.authorUzun, Duygu
dc.contributor.authorFidanol Erboğa, Zeynep
dc.date.accessioned2022-05-11T14:41:25Z
dc.date.available2022-05-11T14:41:25Z
dc.date.issued2011
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractThe aim of this study was to investigate the caspase-3 activity in neuronal apoptosis after experimental closed head trauma model in rats. Twenty adult male rats were randomly divided into two groups: control and trauma groups. In trauma group, a cranial impact was delivered to the skull from a height of 7 cm at a point just in front of the coronal suture and over the right hemisphere. Rats were sacrificed at 12 hours after the onset of injury. Brain tissues were removed for histopathological investigation. In the trauma group, the neurons became extensively dark and degenerated into picnotic nuclei. The number of apoptotic neurons in frontal cortex tissue of trauma group was significantly more than control groups. In conclusion, the caspase 3 immunopositivity was increased in degenerating neurons of the frontal cortex tissue following trauma. The present results indicate that closed head trauma caused degenerative changes and increased caspase 3 immonupositivity in neurons. © 2011 OMU All rights reserved.
dc.identifier.doi10.5835/jecm.omu.28.03.002
dc.identifier.endpage102
dc.identifier.issn1300-2996
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84858815361
dc.identifier.scopusqualityN/A
dc.identifier.startpage99
dc.identifier.urihttps://doi.org/10.5835/jecm.omu.28.03.002
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9174
dc.identifier.volume28
dc.indekslendigikaynakScopus
dc.institutionauthorAktaş, Cevat
dc.language.isoen
dc.relation.ispartofJournal of Experimental and Clinical Medicine (Turkey)
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectApoptosis
dc.subjectBrain tissue
dc.subjectCaspase-3
dc.subjectClosed head trauma
dc.subjectImmunohistochemistry
dc.subjectRat
dc.titleImmunohistochemical investigation of caspase-3 in neuronal apoptosis after experimental closed head trauma
dc.typeArticle

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