Lymphatic vessels accompanying dorsal and basal dural sinuses in the human brain

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dc.authoridOZKAN, Mazhar/0000-0002-8745-2493
dc.authoridCingoz, Ahmet/0000-0002-1111-7752
dc.authoridGURSES, Ilke Ali/0000-0001-9188-4662
dc.contributor.authorCavdar, Safiye
dc.contributor.authorKose, Busra
dc.contributor.authorAltinoz, Damlasu
dc.contributor.authorSoyler, Gizem
dc.contributor.authorCingoz, Ahmet
dc.contributor.authorGurses, Ilke Ali
dc.contributor.authorOzkan, Mazhar
dc.date.accessioned2024-10-29T17:58:27Z
dc.date.available2024-10-29T17:58:27Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractRecent investigations showed the presence of meningeal lymphatic vessels (mLVs) along the superior sagittal and transverse dural sinuses which drain both fluid and immune cells from the cerebrospinal fluid (CSF) to the deep cervical lymph nodes. This study uses immunohistochemistry (IHC) and the Western Blot technique to show the presence of mLV accompanying the dorsal (superior sagittal, inferior sagittal, transverse, sigmoid, and straight) and basal (cavernous, sphenoparietal, superior, and inferior petrosal) dural sinuses in the human brain. Samples for IHC were obtained from dorsal and basal meningeal dural sinuses of 3 human cadavers and 3 autopsies. Routine histological techniques were carried out for the specimens. Podoplanin (PDPN, lymphatic vessel endothelial cell marker) and CD31 (vascular endothelial cell marker) IHC staining were applied to the 5 mu m thick paraffin sections. Furthermore, PDPN and CD31 protein expressions were evaluated using Western Blot to the tissue samples from the same regions of 4 autopsies. Two consecutive sections from each sinus were PDPN, and CD31 was stained to differentiate blood vessels (BV) from mLV. The IHC staining showed the presence of mLVs accompanying both dorsal and basal dural sinuses. The mLVs accompanying the dorsal dural sinuses had a larger dimensions range compared to the basal dural sinuses. However, the number of mLVs along the basal dural sinuses was more than the mLVs along the dorsal ones. Further, fluid channels were closely localized to the mLV, with varying diameters and densities. Western Blotting technique showed the presence of PDPN expression in both dorsal and basal dural sinus samples. The knowledge of the presence of mLV along both dorsal and basal dural sinuses in humans can increase the understanding of how mLV contributes to the brain lymphatic circulation and may help understand the neuropathophysiological processes of various neurological diseases.
dc.identifier.doi10.1016/j.jchemneu.2023.102357
dc.identifier.issn0891-0618
dc.identifier.issn1873-6300
dc.identifier.scopus2-s2.0-85175711106
dc.identifier.scopusqualityQ4
dc.identifier.urihttps://doi.org/10.1016/j.jchemneu.2023.102357
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14322
dc.identifier.volume134
dc.identifier.wosWOS:001110171700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherElsevier
dc.relation.ispartofJournal of Chemical Neuroanatomy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDorsal and basal meningeal sinuses
dc.subjectLymphatic vessels
dc.titleLymphatic vessels accompanying dorsal and basal dural sinuses in the human brain
dc.typeArticle

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