Interleukin 18 gene polymorphism is a risk factor for multiple sclerosis

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dc.authorid0000-0003-0505-7850
dc.authorscopusid54901776800
dc.authorscopusid35574319900
dc.authorscopusid14028431900
dc.authorscopusid16069377400
dc.authorscopusid6603214291
dc.authorscopusid55762639500
dc.authorscopusid55986161400
dc.contributor.authorÇelik, Sevim Karakaş
dc.contributor.authorÖz, Zehra Safi
dc.contributor.authorDursun, Ahmet
dc.contributor.authorÜnal, Aysun
dc.contributor.authorEmre, Ufuk
dc.contributor.authorÇiçek, Salih
dc.contributor.authorKeni, Fatih Mehmet
dc.date.accessioned2022-05-11T14:40:14Z
dc.date.available2022-05-11T14:40:14Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Nöroloji Ana Bilim Dalı
dc.description.abstractProinflammatory cytokines with immunosuppressive properties play an important role in the pathogenesis of multiple sclerosis (MS). Interleukin 18 (IL-18) is one of the most important innate cytokines produced from macrophages in the early stages of the inflammatory immune response. The purpose of this study was to determine whether there was any relationship between IL18 gene polymorphisms and MS. IL18 genotyping were performed in 101 MS patients and 164 control subjects by using the PCR-restriction fragment length polymorphism (PCR-RFLP) method. The frequency of MS patients with the CC genotype of the IL18 gene at position -137 was significantly higher than with the GG genotype [p = 0.01, odds ratio (OR) 3.17]. In haplotype analysis of two SNPs in the IL18 gene, frequency of the CC haplotype was significantly higher in MS patients (p = 0.002, OR 3.0). However, the genotype distribution of the IL18 -607 C/A polymorphism in the MS patient group was not significantly different from that of the control group. These data suggest that IL18 gene polymorphisms at position -137 might be a genetic risk factor for MS in the Turkish population.
dc.identifier.doi10.1007/s11033-013-3013-5
dc.identifier.endpage1658
dc.identifier.issn0301-4851
dc.identifier.issn1573-4978
dc.identifier.issue3en_US
dc.identifier.pmid24402877
dc.identifier.scopus2-s2.0-84896055869
dc.identifier.scopusqualityQ2
dc.identifier.startpage1653
dc.identifier.urihttps://doi.org/10.1007/s11033-013-3013-5
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8914
dc.identifier.volume41
dc.identifier.wosWOS:000332000400052
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÜnal, Aysun
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofMolecular Biology Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectInterleukin 18
dc.subjectPolymorphism
dc.subjectMultiple sclerosis
dc.subjectCytokine
dc.subjectExperimental Autoimmune Encephalomyelitis
dc.subjectMessenger-Rna
dc.subjectIfn-Gamma
dc.subjectDisease
dc.subjectAlpha
dc.subjectSusceptibility
dc.subjectMetaanalysis
dc.subjectAssociation
dc.subjectPromoter
dc.subjectIl-18
dc.titleInterleukin 18 gene polymorphism is a risk factor for multiple sclerosis
dc.typeArticle

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