The Effect of Topical Castellani Solution on Outer Hair Cell Function of Rats

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dc.authorid0000-0002-0932-2773
dc.authorscopusid26648338400
dc.authorscopusid7006196440
dc.authorscopusid57214434799
dc.authorwosidyener, murat/AAK-4605-2020
dc.contributor.authorGültekin, Erdoğan
dc.contributor.authorYener, Murat
dc.contributor.authorÖzdemir, İsmail
dc.date.accessioned2022-05-11T14:36:03Z
dc.date.available2022-05-11T14:36:03Z
dc.date.issued2010
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kulak Burun ve Boğaz Hastalıkları Ana Bilim Dalı
dc.description.abstractObjectives/Hypothesis: To evaluate if Castellani solution, which is used for the treatment of mycotic infections of the car, has any ototoxic potential. There are some studies about the toxic effect of some of the ingredients of the Castellani solution, but the ototoxic effect is not known The current study was designed to investigate the ototoxicity experimentally Study Design: Prospective controlled animal study. Methods: Experiments were performed on 40 male Wistar albino rats. The animals were divided into four groups, each consisting of 10 rats Under general anesthesia, the right tympanic membranes of the all of the rats were perforated and baseline distortion product otoacoustic emission (DPOAE) measurements were performed from the right ears before the use of solutions. The solutions were applied through the ear canal for 2 weeks using 0.1 mL twice a day The rats m group I (study group) received Castellani solution. The rats in group II and group III received gentamicin (40 mg/mL) and saline solution respectively The rats in group IV were followed without use of any medication After 2 weeks DPOAE recordings were repeated. Results: Baseline DPOAE results were normal in the right ears of all animals tested. Animals treated with either Castellani solution or saline and the rats in the control group showed no significant changes in the DPOAE amplitudes. The gentamicin group showed a significant decrease in the DPOAE values Conclusions: In the rat, Castellani solution, which is topically applied to the middle ear cavity, does not affect DPOAE amplitudes
dc.identifier.doi10.1002/lary.20845
dc.identifier.endpage812
dc.identifier.issn0023-852X
dc.identifier.issn1531-4995
dc.identifier.issue4en_US
dc.identifier.pmid20213791
dc.identifier.scopus2-s2.0-77950804785
dc.identifier.scopusqualityQ1
dc.identifier.startpage808
dc.identifier.urihttps://doi.org/10.1002/lary.20845
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8352
dc.identifier.volume120
dc.identifier.wosWOS:000276335100029
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGültekin, Erdoğan
dc.institutionauthorYener, Murat
dc.institutionauthorÖzdemir, İsmail
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofLaryngoscope
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOtotoxicity
dc.subjecttopical application
dc.subjectCastellani
dc.subjectdistortion product otoacoustic emission
dc.subjectMiddle-Ear
dc.subjectOtoacoustic Emissions
dc.subjectOtotoxicity
dc.subjectDrops
dc.titleThe Effect of Topical Castellani Solution on Outer Hair Cell Function of Rats
dc.typeArticle

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