The relationship between mean platelet volume and reverse dipping blood pressure pattern in patients with essential hypertension

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dc.authorid0000-0003-3304-4125
dc.authorscopusid6505680586
dc.authorscopusid57224503376
dc.authorscopusid55317577700
dc.authorscopusid16315021800
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorGokcek, Sumeyra
dc.contributor.authorÖzkaramanlı Gür, Demet
dc.contributor.authorAkyüz, Aydın
dc.date.accessioned2022-05-11T14:40:11Z
dc.date.available2022-05-11T14:40:11Z
dc.date.issued2021
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractObjective An association between increased mean platelet volume (MPV) and cardiovascular events is well established. Recent studies suggest that a nondipper blood pressure pattern is closely related to increased MPV. Because little information has been revealed about the relationship between reverse dipper hypertension (RDHT) and MPV, we aimed to investigate this relation. Methods A total of 317 patients were retrospectively evaluated by analyzing the records of ambulatory blood pressure monitoring (ABPM). Patients were categorized into three groups according to their ABPM values as RDHT (n = 63), non-dipper hypertension (NDHT) (n = 95), and dipper hypertension (DHT) groups (n = 159). MPV and biochemical analyses were recorded from the hospital database. Results The largest MPV was found in patients with RDHT, followed by patients with NDHT and DHT group (9.1 +/- 0.4 fl, 8.8 +/- 0.6 fl, and 8.6 +/- 0.5 fl, respectively, for all p < .05). MPV was positively correlated with mean 24-hour systolic blood pressure (SBP), mean 24-hour diastolic blood pressure (DBP), mean daytime SBP, mean nighttime SBP and mean nighttime DBP. In multivariate logistic regression analysis, MPV (OR 1.761, 95% CI 1.329 to 2.334, p = .001) and age (OR 1.065, 95% CI 1.019 to 1.113, p = .001) were found to be associated with RDHT. ROC curve analysis of MPV for prediction of RDHT showed that at the cutoff value of >9,1 fl with a sensitivity of 60% and specificity of 69%, respectively (AUC = 0.696 +/- 0.035, 95% CI: 0.627-0.764). Our data show that the RDHT pattern is associated with increased MPV values in patients with essential hypertension.
dc.identifier.doi10.1080/10641963.2021.1937203
dc.identifier.endpage676
dc.identifier.issn1064-1963
dc.identifier.issn1525-6006
dc.identifier.issue7en_US
dc.identifier.pmid34120543
dc.identifier.scopus2-s2.0-85107733880
dc.identifier.scopusqualityQ3
dc.identifier.startpage671
dc.identifier.urihttps://doi.org/10.1080/10641963.2021.1937203
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8894
dc.identifier.volume43
dc.identifier.wosWOS:000661034800001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorGokcek, Sumeyra
dc.institutionauthorÖzkaramanlı Gür, Demet
dc.institutionauthorAkyüz, Aydın
dc.language.isoen
dc.publisherTaylor & Francis Inc
dc.relation.ispartofClinical and Experimental Hypertension
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHypertension
dc.subjectreverse dipper
dc.subjectmean platelet volume
dc.subjectblood pressure
dc.subjectpattern
dc.subjectMortality
dc.subjectAssociation
dc.titleThe relationship between mean platelet volume and reverse dipping blood pressure pattern in patients with essential hypertension
dc.typeArticle

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