The effect of oral administration of monosodium glutamate on epileptogenesis in infant rats

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dc.authorscopusid57188876195
dc.authorscopusid7801455102
dc.authorscopusid57216675814
dc.authorscopusid57216677230
dc.authorscopusid57216677105
dc.authorscopusid57216676901
dc.authorscopusid57194586175
dc.contributor.authorDemirkapu, Mahluga Jafarova
dc.contributor.authorYananlı, Hasan Raci
dc.contributor.authorAkşahin, E.
dc.contributor.authorKarabiber, C.
dc.contributor.authorGünay, P.
dc.contributor.authorKekilli, A.
dc.contributor.authorTopkara, B.
dc.date.accessioned2022-05-11T14:05:09Z
dc.date.available2022-05-11T14:05:09Z
dc.date.issued2020
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractAim: Glutamate is an excitatory neurotransmitter that is widely distributed throughout the brain. An increase in glutamate concentration or sensitivity of glutamate receptors triggers neurodegenerative diseases, epilepsy in particular. Monosodium glutamate is a substance added to foods to enhance flavour. We investigated the effect of monosodium glutamate on epileptogenesis, as well asheight and weight, in rats that were just weaned. Methods: Twenty-four male and female 21-day-old Wistar Albino rats were divided into two groups: one with monosodium glutamate added to the drinking water, and a control in which NaCl was added to the drinking water. The electrical stimulation threshold values were determined in animals to which the hippocampal kindling process was applied, and the stimulations at these threshold values were invariably applied to the animals until they were kindled. Results: The electrical stimulation threshold values of the monosodium glutamate group did not statistically change, whereas the number of required stimulations for kindled rats was significantly lower compared with the control group. Conclusion: These results reveal that long-term oral administration of glutamate salts causes an increase in excitability in the central nervous system during ontogenetic development. © 2020 Epileptic Disorders
dc.identifier.doi10.1684/epd.2020.1156
dc.identifier.endpage201
dc.identifier.issn1294-9361
dc.identifier.issue2en_US
dc.identifier.pmid32310135
dc.identifier.scopus2-s2.0-85084271535
dc.identifier.scopusqualityQ2
dc.identifier.startpage195
dc.identifier.urihttps://doi.org/10.1684/epd.2020.1156
dc.identifier.urihttps://hdl.handle.net/20.500.11776/4909
dc.identifier.volume22
dc.identifier.wosWOS:000530695900007
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDemirkapu, Mahluga Jafarova
dc.language.isoen
dc.publisherJohn Libbey
dc.relation.ispartofEpileptic Disorders
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectepilepsy
dc.subjectglutamate
dc.subjecthippocampus
dc.subjectkindling
dc.subjectdrinking water
dc.subjectglutamate sodium
dc.subjectketamine
dc.subjectneurotransmitter
dc.subjectglutamate sodium
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectArticle
dc.subjectbody weight
dc.subjectcomparative study
dc.subjectelectroencephalogram
dc.subjectelectroencephalography
dc.subjectelectrostimulation
dc.subjectepilepsy
dc.subjectepileptogenesis
dc.subjectinfant
dc.subjectkindling
dc.subjectnonhuman
dc.subjectpriority journal
dc.subjectrat
dc.subjectanimal
dc.subjectbrain cortex
dc.subjectdisease model
dc.subjectdrug effect
dc.subjectelectrocorticography
dc.subjectepilepsy
dc.subjectfemale
dc.subjecthippocampus
dc.subjectmale
dc.subjectpathophysiology
dc.subjectWistar rat
dc.subjectAnimals
dc.subjectCerebral Cortex
dc.subjectDisease Models, Animal
dc.subjectElectric Stimulation
dc.subjectElectrocorticography
dc.subjectEpilepsy
dc.subjectFemale
dc.subjectHippocampus
dc.subjectKindling, Neurologic
dc.subjectMale
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSodium Glutamate
dc.titleThe effect of oral administration of monosodium glutamate on epileptogenesis in infant rats
dc.typeArticle

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