Comparison of Ovulation Induction Protocols After Endometrioma Resection

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dc.authorid0000-0002-7183-1456
dc.authorid0000-0003-0810-6195
dc.authorwosidUgurlucan, Funda Gungor/AAD-3082-2020
dc.authorwosidDural, Ozlem/AAY-2248-2020
dc.authorwosidBastu, Ercan/K-5354-2017
dc.authorwosidYasa, Cenk/K-9844-2016
dc.contributor.authorBastu, Ercan
dc.contributor.authorYasa, Cenk
dc.contributor.authorDural, Özlem
dc.contributor.authorMutlu, Mehmet Firat
dc.contributor.authorÇelik, Cem
dc.contributor.authorUğurlucan, Funda Güngör
dc.contributor.authorBuyru, Faruk
dc.date.accessioned2022-05-11T14:35:51Z
dc.date.available2022-05-11T14:35:51Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractBackground and Objectives: The aim of this study was to compare the in vitro fertilization (IVF) outcomes of long gonadotropin-releasing hormone agonist (GnRH-a) and GnRH-antagonist (GnRH-ant) protocols in endometriosis patients who have undergone laparoscopic endometrioma resection surgery. To our knowledge, there is no study in the current literature that compares the effectiveness of long GnRH-a and GnRH-ant protocols in management of IVF cycles in endometriosis patients who underwent laparoscopic endometrioma resection surgery. Methods: Eighty-six patients with stage III to IV endometriosis who had undergone laparoscopic resection surgery for endometrioma were divided into 2 groups: those who had ovarian stimulation with a long GnRH-a protocol (n = 44), and those who had ovarian stimulation with a GnRHant protocol (n = 42). Results: The number of follicles on human chorionic gonadotropin injection day, duration of hyperstimulation, number of retrieved metaphase II oocytes, and total number of grade 1 embryos were statically significantly higher in the long GnRH-a protocol. There were no significant differences in positive beta-human chorionic gonadotropin pregnancy rates (25% vs 21.4%; P = .269) and ongoing pregnancy rates per patient (20.5% vs 19.1%; P = .302) between the 2 protocols. Conclusions: Long GnRH-a and GnRH-ant protocols both present similar IVF outcomes in patients with endometriosis who have undergone laparoscopic endometrioma resection surgery. A long GnRH-a protocol may lead to a higher number of embryos that can be cryopreserved, providing the possibility of additional embryo transfers without having to go through the process of ovarian stimulation again.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul UniversityIstanbul University [33502]
dc.description.sponsorshipAn earlier version of this research was presented at the 29th Annual Meeting of the European Society of Human Reproduction and Embryology in London, 2013. This was made possible by funding from the Scientific Research Projects Coordination Unit of Istanbul University (#33502).
dc.identifier.doi10.4293/JSLS.2014.00128
dc.identifier.issn1086-8089
dc.identifier.issue3en_US
dc.identifier.pmid25392665
dc.identifier.urihttps://doi.org/10.4293/JSLS.2014.00128
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8265
dc.identifier.volume18
dc.identifier.wosWOS:000348437400023
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.institutionauthorÇelik, Cem
dc.language.isoen
dc.publisherSoc Laparoendoscopic Surgeons
dc.relation.ispartofJsls-Journal of the Society of Laparoendoscopic Surgeons
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGnRH antagonist
dc.subjectGnRH agonist
dc.subjectLaparoscopic endometrioma resection
dc.subjectin vitro fertilization
dc.subjectintracytoplasmic sperm injection
dc.subjectIn-Vitro Fertilization
dc.subjectHormone Gnrh Analog
dc.subjectOvarian Stimulation
dc.subjectPregnancy Rates
dc.subjectAssisted Reproduction
dc.subjectDown-Regulation
dc.subjectEmbryo-Transfer
dc.subjectWomen
dc.subjectIvf
dc.subjectAntagonist
dc.titleComparison of Ovulation Induction Protocols After Endometrioma Resection
dc.typeArticle

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