Comparison of Ovulation Induction Protocols After Endometrioma Resection

Yükleniyor...
Küçük Resim

Tarih

2014

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Soc Laparoendoscopic Surgeons

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Background and Objectives: The aim of this study was to compare the in vitro fertilization (IVF) outcomes of long gonadotropin-releasing hormone agonist (GnRH-a) and GnRH-antagonist (GnRH-ant) protocols in endometriosis patients who have undergone laparoscopic endometrioma resection surgery. To our knowledge, there is no study in the current literature that compares the effectiveness of long GnRH-a and GnRH-ant protocols in management of IVF cycles in endometriosis patients who underwent laparoscopic endometrioma resection surgery. Methods: Eighty-six patients with stage III to IV endometriosis who had undergone laparoscopic resection surgery for endometrioma were divided into 2 groups: those who had ovarian stimulation with a long GnRH-a protocol (n = 44), and those who had ovarian stimulation with a GnRHant protocol (n = 42). Results: The number of follicles on human chorionic gonadotropin injection day, duration of hyperstimulation, number of retrieved metaphase II oocytes, and total number of grade 1 embryos were statically significantly higher in the long GnRH-a protocol. There were no significant differences in positive beta-human chorionic gonadotropin pregnancy rates (25% vs 21.4%; P = .269) and ongoing pregnancy rates per patient (20.5% vs 19.1%; P = .302) between the 2 protocols. Conclusions: Long GnRH-a and GnRH-ant protocols both present similar IVF outcomes in patients with endometriosis who have undergone laparoscopic endometrioma resection surgery. A long GnRH-a protocol may lead to a higher number of embryos that can be cryopreserved, providing the possibility of additional embryo transfers without having to go through the process of ovarian stimulation again.

Açıklama

Anahtar Kelimeler

GnRH antagonist, GnRH agonist, Laparoscopic endometrioma resection, in vitro fertilization, intracytoplasmic sperm injection, In-Vitro Fertilization, Hormone Gnrh Analog, Ovarian Stimulation, Pregnancy Rates, Assisted Reproduction, Down-Regulation, Embryo-Transfer, Women, Ivf, Antagonist

Kaynak

Jsls-Journal of the Society of Laparoendoscopic Surgeons

WoS Q Değeri

Q3

Scopus Q Değeri

Cilt

18

Sayı

3

Künye