Radiation synthesis and characterization of chitosan/hyraluronic acid/hydroxyapatite hydrogels: drug uptake and drug delivery systems

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dc.authorscopusid57189078413
dc.authorscopusid55043447800
dc.authorscopusid54584905800
dc.authorwosidTaşdelen, Betül/ABA-6295-2020
dc.contributor.authorTaşdelen, Betül
dc.contributor.authorErdoğan, Sevil
dc.contributor.authorBekar, Bahadır
dc.date.accessioned2022-05-11T14:16:05Z
dc.date.available2022-05-11T14:16:05Z
dc.date.issued2018
dc.departmentFakülteler, Çorlu Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.description14th International Conference on Nanosciences and Nanotechnologies (NN) -- JUL 04-07, 2017 -- Thessaloniki, GREECE
dc.description.abstractIn this work, a new chitosan (CS)/hyaluronic acid (HA)/hydroxyapatite (HAP) hydrogels were synthesized by using gamma rays irradiation technique for oral delivery of drugs. The hydrogelss were characterized using fourier transform infrared spectroscopy (FTIR) and the physicochemical properties of shrimp chitosan was determined with both FTIR and scanning electron microscopy (SEM). The use of the hydrogel samples as a drug delivery system was investigated by an anticancer drug. 5-Fluorouracil (5-FU) was used as a model anticancer drug to investigate the drug uptake and release kinetics of hydrogels. The properties of the hydrogels were evaluated in terms of swelling, drug uptake and release behaviours. The addition of hyaluronic acid and hydroxyapatite in the gel structure improved drug uptake and release capability of the new hydrogels. (c) 2018 Elsevier Ltd. All rights reserved. Selection and/or Peer-review under responsibility of 14th International Conference on Nanosciences & Nanotechnologies (NN17).
dc.description.sponsorshipNamik Kemal University Scientific Research ProjectNamik Kemal University [NKUBAP.00.17.AR.14.14]
dc.description.sponsorshipThe authors acknowledge Namik Kemal University Scientific Research Project (NKUBAP.00.17.AR.14.14) for funding.
dc.identifier.doi10.1016/j.matpr.2018.05.043
dc.identifier.endpage15997
dc.identifier.issn2214-7853
dc.identifier.issue8en_US
dc.identifier.scopus2-s2.0-85056511434
dc.identifier.scopusqualityQ2
dc.identifier.startpage15990
dc.identifier.urihttps://doi.org/10.1016/j.matpr.2018.05.043
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6175
dc.identifier.volume5
dc.identifier.wosWOS:000441006800006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorTaşdelen, Betül
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofMaterials Today-Proceedings
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectHydrogels
dc.subjectchitosan
dc.subjecthyaluronic acid
dc.subjecthydroxiapatite
dc.subjectdrug delivery
dc.subjectPhysicochemical Characterization
dc.subjectHydroxyapatite Nanoparticles
dc.subjectPharmaceutical Applications
dc.subjectChitosan
dc.subjectChitin
dc.subjectLiver
dc.titleRadiation synthesis and characterization of chitosan/hyraluronic acid/hydroxyapatite hydrogels: drug uptake and drug delivery systems
dc.typeConference Object

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