Association of fetuin a, adiponectin, interleukin 10 and total antioxidant capacity with IVF outcomes

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dc.authorscopusid56545150500
dc.authorscopusid6602805712
dc.authorscopusid6504423519
dc.authorscopusid13611300300
dc.authorscopusid55396163300
dc.authorscopusid57226739123
dc.authorscopusid53881342200
dc.contributor.authorYen, Mustafa
dc.contributor.authorDonma, Orkide
dc.contributor.authorYıldızfer, Ferdağ
dc.contributor.authorEkmekci, Özlem
dc.contributor.authorKarataş Kul, Zübeyde Aslı
dc.contributor.authorİmal, A. Esat
dc.contributor.authorDonma, Mustafa Metin
dc.date.accessioned2022-05-11T14:37:13Z
dc.date.available2022-05-11T14:37:13Z
dc.date.issued2014
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Possible roles of anti-inflammatory factors as well as total antioxidative capacity in reproductive processes of women undergoing in vitro fertilization (IVF) are still being investigated and the contributions by some of them remain controversial. Objective: The aim of this study is to investigate the relationship between antiinflammatory parameters and total antioxidative capacity (TAC) of the body during IVF. In this respect, adiponectin, interleukin-10 (IL-10), interleukin-1 receptor antagonist (IL-1RA), fetuin A and TAC analyses have been performed. Materials and Methods: In this prospective, non-randomized, controlled clinical study, sera obtained from 26 fertile (Group-1), and 26 infertile women before (Group-2) and after (Group-3) IVF treatment were analyzed. IL-1RA, IL-10, fetuin A, adiponectin and insulin were determined by ELISA. TAC was determined spectrophotometrically. Mann-Whitney U test, paired sample t-test, Wilcoxon signed-rank test as well as Pearson correlation analysis by SPSS were performed for statistical analysis. Results: Clinical pregnancy and live birth rates were determined as 30.8% and 23.1%, respectively, in pregnant group. For the pregnant, significant indirect correlations were detected between fetuin A and adiponectin (r=-0.843; p=0.035) as well as IL-10 (r=-0.846; p=0.034) in Group 2. The correlation between adiponectin and IL-10 doubled in pregnant compared to non-pregnant (r=0.929; p=0.007 vs. r=0.478; p=0.033). The correlations between fetuin A and TAC in pregnant were noted both in Group 2 (r=0.892; p=0.017) and Group 3 (r=0.875; p=0.022). No correlation of fetuin A with these parameters was detected in non-pregnant group. Conclusion: Fetuin A, TAC, IL-10, adiponectin and their associations may be important from their predictive values for IVF success point of view. Parameters with anti-inflammatory or antioxidant property appear to improve pregnancy in women undergoing IVF. © Research and Clinical Center for Infertitlity. All rights reserved.
dc.identifier.endpage754
dc.identifier.issn1680-6433
dc.identifier.issue11en_US
dc.identifier.scopus2-s2.0-84924618459
dc.identifier.scopusqualityN/A
dc.identifier.startpage747
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8622
dc.identifier.volume12
dc.indekslendigikaynakScopus
dc.institutionauthorDonma, Mustafa Metin
dc.language.isoen
dc.publisherResearch and Clinical Center for Infertitlity
dc.relation.ispartofIranian Journal of Reproductive Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAdiponectin
dc.subjectFetuin A
dc.subjectInfertility
dc.subjectInterleukin 10
dc.subjectInterleukin 1RA
dc.subjectadiponectin
dc.subjectfetuin A
dc.subjectinsulin
dc.subjectinterleukin 1 receptor blocking agent
dc.subjectinterleukin 10
dc.subjectadult
dc.subjectArticle
dc.subjectcontrolled study
dc.subjectfemale
dc.subjectfemale infertility
dc.subjectfertilization in vitro
dc.subjecthuman
dc.subjectlive birth
dc.subjectmajor clinical study
dc.subjectmetabolic parameters
dc.subjectpredictive value
dc.subjectpregnancy rate
dc.subjectprospective study
dc.subjecttotal antioxidant capacity
dc.titleAssociation of fetuin a, adiponectin, interleukin 10 and total antioxidant capacity with IVF outcomes
dc.typeArticle

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