Protective Effect of Curcumin on Liver Damage Induced by Biliary Obstruction in Rats

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dc.authorscopusid6603033479
dc.authorscopusid7006356462
dc.authorscopusid16443917200
dc.authorscopusid38762072100
dc.authorscopusid6507986716
dc.authorscopusid24436194200
dc.authorscopusid36023238400
dc.authorwosidAktas, Cevat/D-8468-2011
dc.contributor.authorErenoglu, Cengiz
dc.contributor.authorKanter, Mehmet
dc.contributor.authorAksu, Burhan
dc.contributor.authorSağıroğlu, Tamer
dc.contributor.authorAyvaz, Süleyman
dc.contributor.authorAktaş, Cevat
dc.contributor.authorErboğa, Mustafa
dc.date.accessioned2022-05-11T14:41:25Z
dc.date.available2022-05-11T14:41:25Z
dc.date.issued2011
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalı
dc.description.abstractObjective: The aim of this study is to evaluate the possible protective effects of curcumin against cholestatic oxidative stress and liver damage in common bile duct ligated rats. Material and Methods: A total of 18 male Wistar albino rats were divided into three groups: control, common bile duct ligation (BDL) and BDL+curcumin. Each group contained 6 animals. The rats in the curcumin treated group were given curcumin (100 mg/kg) once a day orally for 14 days, starting 3 days prior to BDL operation. Following 14 days of treatment, all the animals were decapitated and liver tissue samples were obtained for histopathological investigation. Results: The changes demonstrating the bile duct proliferation and fibrosis in expanded portal tracts, including the extension of proliferated bile ducts into lobules, mononuclear cells, and neutrophil infiltration into the widened portal areas, were observed in BDL group. Treatment of BDL with curcumin attenuated liver damage. Both the elevated alpha smooth muscle actin (alpha-SMA), and the activity of TUNEL in the BDL were observed to be reduced with the curcumin treatment. Conclusion: Our data indicate that curcumin reduced BDL-induced cholestatic liver injury, bile duct proliferation, fibrosis.
dc.identifier.doi10.5174/tutfd.2010.04312.1
dc.identifier.endpage357
dc.identifier.issn2146-3123
dc.identifier.issn2146-3131
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-82155203015
dc.identifier.scopusqualityQ3
dc.identifier.startpage352
dc.identifier.urihttps://doi.org/10.5174/tutfd.2010.04312.1
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9176
dc.identifier.volume28
dc.identifier.wosWOS:000297455600002
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorAktaş, Cevat
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofBalkan Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCurcumin
dc.subjectimmunohistochemistry
dc.subjectTUNEL
dc.subjectliver
dc.subjectbile duct ligation
dc.subjectNitric-Oxide Synthase
dc.subjectBile-Duct Obstruction
dc.subjectHepatic-Fibrosis
dc.subjectExpression
dc.subjectInhibition
dc.subjectAcid
dc.subjectCirrhosis
dc.subjectInjury
dc.subjectMyofibroblast
dc.subjectModulation
dc.titleProtective Effect of Curcumin on Liver Damage Induced by Biliary Obstruction in Rats
dc.typeArticle

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