Systemic Immune-Inflammatory Index as a Determinant of Atherosclerotic Burden and High-Risk Patients with Acute Coronary Syndromes

Basit Öğe Kaydı
dc.authoridÇELIKKOL, ALIYE/0000-0002-3799-4470
dc.authoridalpsoy, seref/0000-0003-3720-0076
dc.authorscopusid55317577700
dc.authorscopusid57226870481
dc.authorscopusid6505680586
dc.authorscopusid16315021800
dc.authorscopusid57877098900
dc.authorscopusid57218879837
dc.authorscopusid10139012600
dc.authorwosidÇELIKKOL, ALIYE/ABE-2695-2020
dc.contributor.authorGür, Demet Özkaramanlı
dc.contributor.authorEfe, Muhammet Mucip
dc.contributor.authorAlpsoy, Şeref
dc.contributor.authorAkyüz, Aydın
dc.contributor.authorUslu, Nurullah
dc.contributor.authorÇelikkol, Aliye
dc.contributor.authorGür, Özcan
dc.date.accessioned2023-04-20T08:01:14Z
dc.date.available2023-04-20T08:01:14Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Kardiyoloji Ana Bilim Dalı
dc.description.abstractBackground: Systemic immune-inflammatory index (SII), which is derived from neutrophil, platelet and lymphocyte counts, represents the homeostatic balance among inflammatory, immune and thrombotic status. The systemic immune-inflammatory index is superior to indices such as neutrophil-lymphocyte ratio in predicting prognosis in various malignancies, while it is shown to predict future cardiac events better than traditional risk factors after coronary intervention. Objectives: Herein, we aimed to evaluate the relationship of the systemic immune-inflammatory index with atherosclerotic burden and in-hospital complications in acute coronary syndrome patients. Methods: The clinical outcomes, such as extent of myocardial damage, atherosclerotic burden, bleeding, acute kidney injury, duration of hospital stay and in-hospital mortality, were evaluated in a retrospective cohort of 309 consecutive acute coronary syndrome patients. The systemic immune-inflammatory index was calculated as (Platelet X Neutrophil)/Lymphocyte count on admission. Study population was categorized into tertiles with regard to systemic immune-inflammatory index. A p value of <0.05 was considered statistically significant. Results: The highest systemic immune-inflammatory index values were within ST elevation myocardial infarction patients (641.4 in unstable angina pectoris, 843.0 in non-ST elevation myocardial infarction patients and 996.0 in ST elevation myocardial infarction patients; p=0.004). Maximal troponin concentration (0.94 vs. 1.26 vs. 3; p<0.001), number of diseased vessels (1 vs. 2 vs. 2; p<0.001), the SYNTAX (synergy between percutaneous coronary intervention with taxus and coronary artery bypass grafting) score (9 vs. 14 vs. 17.5; p<0.001) and duration of hospital stay (2 vs. 2 vs. 3; p<0.001) also increased with increasing SIItertile (tertile1 vs. tertile 2 vs. tertile 3). Systemic immune-inflammatory index was an independent predictor of SYNTAX score (B: 0.232 [0.001 to 0.003]; p<0.001), extent of myocardial damage (B: 0.152 [0 to 0.001]; p=0.005) and duration of hospital stay (B: 0.168 [0.0 to 0.001]; p=0.003). Conclusions: This study has demonstrated that the systemic immune-inflammatory index, a simple hematological index, is a marker of atherosclerotic burden and longer hospital stay on well-known risk factors in high risk acute coronary syndrome patients.
dc.identifier.doi10.36660/abc.20210416
dc.identifier.endpage390
dc.identifier.issn0066-782X
dc.identifier.issue3en_US
dc.identifier.pmid35766615
dc.identifier.scopus2-s2.0-85137323298
dc.identifier.scopusqualityQ3
dc.identifier.startpage382
dc.identifier.urihttps://doi.org/10.36660/abc.20210416
dc.identifier.urihttps://hdl.handle.net/20.500.11776/10818
dc.identifier.volume119
dc.identifier.wosWOS:000854003100005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGür, Demet Özkaramanlı
dc.institutionauthorEfe, Muhammet Mucip
dc.institutionauthorAlpsoy, Şeref
dc.institutionauthorAkyüz, Aydın
dc.institutionauthorUslu, Nurullah
dc.institutionauthorÇelikkol, Aliye
dc.institutionauthorGür, Özcan
dc.language.isoen
dc.publisherArquivos Brasileiros Cardiologia
dc.relation.ispartofArquivos Brasileiros De Cardiologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectInflammation
dc.subjectAcute Coronary Syndrome
dc.subjectCoronary Artery Disease
dc.subjectSt-Segment Elevation
dc.subjectNeutrophil-Lymphocyte Ratio
dc.subjectAcute Myocardial-Infarction
dc.subjectPrognostic Value
dc.subjectArtery-Disease
dc.subjectComplexity
dc.subjectEvents
dc.subjectCount
dc.titleSystemic Immune-Inflammatory Index as a Determinant of Atherosclerotic Burden and High-Risk Patients with Acute Coronary Syndromes
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
10818.pdf
Boyut:
680.14 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu