Pathogenetic and Prognostic Importance of Cyclin D1, Estrogen Receptor, and TAG72 in Cutaneous Vascular Tumors and Pericytic Tumors

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dc.authoridMirioglu, Akif/0000-0002-9686-4991
dc.authoridzorlu, ozge/0000-0001-5555-130X
dc.contributor.authorKarabağ, Sevil
dc.contributor.authorErdoğan, Kıvılcım
dc.contributor.authorMirioğlu, Akif
dc.contributor.authorZorlu, Özge
dc.contributor.authorGönlüşen, Gülfiliz
dc.contributor.authorÖzbarlas, Serdar
dc.date.accessioned2023-05-06T17:19:34Z
dc.date.available2023-05-06T17:19:34Z
dc.date.issued2022
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Tıbbi Patoloji Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Deri ve Zührevi Hastalıkları Ana Bilim Dalı
dc.description.abstractObjective: The present study aims to investigate the presence of pericyte loss in malignant vascular tumors and investigate the expression of cell cycle regulators, cyclin D1 and estrogen receptor (ER), and tumor-associated glycoprotein 72 (TAG72) in tumor cells and tumor microenvironment in benign/malignant vascular tumors and benign/malignant pericytic tumors. Methods: Cyclin D1, ER, and TAG72 were examined by immunohistochemistry in 38 cases of tumors of vascular and pericytic origins. The data on metastasis and prognosis of malignant cases were retrieved from the hospital information system. Results: The 38 patients included the following types of neoplasms: hemangioma (n=16), glomus tumor (n=9), epithelioid angiosarcoma (n=8), epithelioid hemangioendothelioma (n=3), infantile hemangiopericytoma (n=1), and malignant glomus tumor (n=1). No statistically significant difference was found in cyclin D1 expression between pericyte-derived tumors and malignant vascular tumors (p=0.508). When benign-malignant vascular and pericytic tumors were compared, no statistically significant difference was found in cyclin D1 expression between the 4 groups (p=0.465). No statistically significant difference was observed in staining between tumors of vascular and pericytic origin (p=0.104). ER expression was detected in only one case of malignant glomus tumor. TAG72 expression was not observed in any of the cases. Conclusion: The present study supports the notion that cyclin D1 may be present as a driver mutation in this group of tumors. The findings of this study did not produce any data to support the hypothesis claiming that pericyte loss led to malignancy. We believe that our results on the comparison of cell cycle protein expressions in cutaneous vascular and pericytic tumors shed light for future studies to elucidate the pathogenesis of this group of rare tumors.
dc.identifier.doi10.4274/jarem.galenos.2022.35220
dc.identifier.endpage142
dc.identifier.issn2146-6505
dc.identifier.issn2147-1894
dc.identifier.issue3en_US
dc.identifier.startpage137
dc.identifier.trdizinid1172365
dc.identifier.urihttps://doi.org/10.4274/jarem.galenos.2022.35220
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11855
dc.identifier.volume12
dc.identifier.wosWOS:000908748300006
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorKarabağ, Sevil
dc.institutionauthorZorlu, Özge
dc.language.isoen
dc.publisherGalenos Publ House
dc.relation.ispartofJournal Of Academic Research In Medicine-Jarem
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectVascular tumor
dc.subjectpericyte
dc.subjectcyclin D1
dc.subjectestrogen receptor
dc.subjectTAG72
dc.subjectB72.3
dc.subjectStage
dc.titlePathogenetic and Prognostic Importance of Cyclin D1, Estrogen Receptor, and TAG72 in Cutaneous Vascular Tumors and Pericytic Tumors
dc.typeArticle

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