Evaluation of SCUBE-1 and sCD40L biomarkers in patients with hypothyroidism due to Hashimoto's thyroiditis: a single-blind, controlled clinical study

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dc.authorid0000-0003-2003-6337
dc.authorid0000-0003-2112-4056
dc.authorscopusid56715752200
dc.authorscopusid55556342300
dc.authorscopusid57200105523
dc.authorscopusid35197435300
dc.authorscopusid55624501100
dc.authorscopusid54892706700
dc.authorscopusid53663196500
dc.authorwosidYILMAZ, Ibrahim/H-6199-2019
dc.authorwosidBaykız, Derya/ABD-7865-2020
dc.authorwosidBilir, Bülent/AAK-5656-2021
dc.contributor.authorBilir, Bülent
dc.contributor.authorSoysal Atile, Neslihan
dc.contributor.authorBilir, Betül Ekiz
dc.contributor.authorYılmaz, I.
dc.contributor.authorBali, İlhan
dc.contributor.authorAltıntaş, Nejat
dc.contributor.authorGüldiken, Sibel
dc.contributor.authorAydın, M.
dc.date.accessioned2022-05-11T14:09:56Z
dc.date.available2022-05-11T14:09:56Z
dc.date.issued2016
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Genel Cerrahi Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Göğüs Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.description.abstractOBJECTIVE: This study was performed to investigate the levels of platelet activation marker SCUBE-1 and sCD40L which plays some role in the progression of atherosclerosis, in patients with hypothyroidism due to Hashimoto's thyroiditis. PATIENTS AND METHODS: The cohort of this study includes 90 patients and 35 healthy volunteers, who admitted to the internal medicine outpatient. Simultaneously in the same samples; SCUBE-1 and sCD40L measurements were accomplished by enzyme-linked immunosorbent assay (ELISA). The data obtained were analyzed statistically. RESULTS: Hypothyroidism due to Hashimoto's thyroiditis in comparison to the control group that includes healthy volunteers; SCUBE-1 and sCD40L, were increased. And these results were statistically significant (p < 0.05). CONCLUSIONS: SCUBE-1 and sCD40L levels were increased in Hashimoto's hypothyroidism patients. This may indicate an increased endothelial dysfunction, platelet activation and cardiovascular risk in hypothyroidism. SCUBE-1 and sCD40L may be helpful in cardiovascular risk assessment of hypothyroid patients.
dc.identifier.endpage413
dc.identifier.issn1128-3602
dc.identifier.issue3en_US
dc.identifier.pmid26914113
dc.identifier.scopus2-s2.0-84987629335
dc.identifier.scopusqualityQ2
dc.identifier.startpage407
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5210
dc.identifier.volume20
dc.identifier.wosWOS:000371386300005
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorBilir, Bülent
dc.institutionauthorBali, İlhan
dc.institutionauthorAltıntaş, Nejat
dc.institutionauthorAydın, M.
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.ispartofEuropean Review For Medical and Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectCardiovascular risk
dc.subjectsCD40L
dc.subjectHypothyroidism
dc.subjectHashimoto's thyroiditis
dc.subjectSCUBE-1
dc.subjectDomain-Containing Protein-1
dc.subjectAcute Coronary Syndromes
dc.subjectSubclinical Hypothyroidism
dc.subjectHypertensive Patients
dc.subjectPlatelet Activation
dc.subjectSerum-Levels
dc.subjectPeptide
dc.subjectEndocan
dc.subjectRisk
dc.subjectExpression
dc.titleEvaluation of SCUBE-1 and sCD40L biomarkers in patients with hypothyroidism due to Hashimoto's thyroiditis: a single-blind, controlled clinical study
dc.typeArticle

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