Alpha B-crystallin Ameliorates Imbalance of Redox Homeostasis, Inflammation and Apoptosis in an Acute Lung Injury Model with Rats

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dc.contributor.authorKocak, Seda
dc.contributor.authorGuner, Ibrahim
dc.contributor.authorYaman, Muhittin Onur
dc.contributor.authorYilmaz, Tugba E. K. I. Z.
dc.contributor.authorGuzel Meydanli, Emine Elif
dc.contributor.authorYelmen, Nermin
dc.contributor.authorSahin, Gulderen
dc.date.accessioned2024-10-29T17:59:34Z
dc.date.available2024-10-29T17:59:34Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesien_US
dc.description.abstractObjective: Ischemia-reperfusion (IR) of the aorta is a significant contributor to the development of postoperative acute lung damage after abdominal aortic surgery. The aim of the present study was to examine the effect of alpha B-crystallin, a small heat shock protein (known as HspB5), on lung injury induced by abdominal aortic IR in rats. Methods: Male Sprague-Dawley rats were divided into three groups: control, ischemia-reperfusion (IR, 90 min ischemia and 180 min reperfusion), and alpha B-crystallin +IR. Alpha B-crystallin (50 mu g/100 g) was intraperitoneally administered 1 h before IR. Lung tissue samples were obtained for histological and biochemical analyses of oxidative stress and cytokine and apoptosis parameters in plasma, lung tissues, and bronchoalveolar lavage (BAL) fluid. Results: The levels of malondialdehyde, reactive oxygen species, total oxidant status, tumor necrosis factor-alpha (TNF-a), interleukin-1 beta (IL-1(3), nuclear factor kappa B (NFK(3), caspase-9 (CASP-9), 8-hydroxy2'-deoxyguanosine, total antioxidant status, superoxide dismutase, and interleukin-1 0 levels in lung tissues, plasma, and BAL fluid (p<0.0 5 versus control) increased in Aortic IR. However, alpha B-crystallin significantly reduced the lung tissue levels of oxidative, inflamatuvar, and apoptotic parameters in the plasma, lung tissues, and BAL fluid (p<0.05 versus aortic IR). Histopathological results showed that alpha B-crystallin ameliorated the morphological changes related to lung injury (p<0.001). Conclusion: Alpha Alpha B-crystallin substantially restored disrupted the redox balance, inflammation, and apoptotic parameters in rats exposed to IR. The cytoprotective effect of alpha B-crystallin on redox balance might be attributed to improved lung injury.en_US
dc.description.sponsorshipIstanbul University Scientific Research Projects [46006]; Council of Higher Education Faculty Member Training Programen_US
dc.description.sponsorshipFinancial Disclosure: This study was supported by Istanbul University Scientific Research Projects under Grant (project number: 46006) and Council of Higher Education Faculty Member Training Program.en_US
dc.identifier.doi10.4274/MMJ.galenos.2024.82274
dc.identifier.endpage220en_US
dc.identifier.issn2149-2042
dc.identifier.issn2149-4606
dc.identifier.issue3en_US
dc.identifier.pmid39350576en_US
dc.identifier.scopus2-s2.0-85206592107en_US
dc.identifier.startpage211en_US
dc.identifier.urihttps://doi.org/10.4274/MMJ.galenos.2024.82274
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14776
dc.identifier.volume39en_US
dc.identifier.wosWOS:001333612200008en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofMedeniyet Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAbdominal surgeryen_US
dc.subjectcytokinesen_US
dc.subjectinflammationen_US
dc.subjectimmunologyen_US
dc.subjectischemia-reperfusionen_US
dc.titleAlpha B-crystallin Ameliorates Imbalance of Redox Homeostasis, Inflammation and Apoptosis in an Acute Lung Injury Model with Ratsen_US
dc.typeArticleen_US

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