The protective effects of omega-3 fatty acids on doxorubicin-induced hepatotoxicity and nephrotoxicity in rats

Basit Öğe Kaydı
dc.authorscopusid8514414100
dc.authorscopusid36866111300
dc.authorscopusid55881189500
dc.authorscopusid37058172000
dc.authorscopusid25647609500
dc.authorscopusid55558318400
dc.authorwosidUYGUR, EMİNE/AAC-4470-2020
dc.contributor.authorTülübaş, Feti
dc.contributor.authorGürel, Ahmet
dc.contributor.authorOran, Mustafa
dc.contributor.authorTopçu, Birol
dc.contributor.authorÇağlar, Veli
dc.contributor.authorUygur, Emine
dc.date.accessioned2022-05-11T14:07:37Z
dc.date.available2022-05-11T14:07:37Z
dc.date.issued2015
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, İç Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Biyoistatistik Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Anatomi Ana Bilim Dalı
dc.departmentMeslek Yüksekokulları, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümü
dc.description.abstractThis study aims to evaluate the protective effects of omega-3 fatty acids (FAs) on doxorubicin (DOX)-induced hepatotoxicity and nephrotoxicity in rats. A total of 24 adult male Sprague Dawley rats were divided into three groups. Control group was given only saline by intragastric gavage. DOX group received DOX at the dose of 30 mg/kg intraperitoneally on day 28. DOX-omega-3 FA group was given as omega-3 FAs at the dose of 400 mg/kg daily by intragastric gavage for 30 days and received DOX at the dose of 30 mg/kg intraperitoneally on day 28. At the end of the 30-day experimental period, the serum, liver and kidney tissue specimens were taken from the animals by giving a general anesthesia. Glutathione (GSH) and malondialdehyde (MDA) levels in serum and GSH and MDA levels and superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities in liver and kidney tissues were measured spectrophotometrically. In our study, a significant increase in MDA levels was observed in rats when given a dose of DOX and a significant decrease in the levels of GSH, SOD and GSH-Px activities in serum, liver and kidney tissues was determined when compared with control group. In addition, a significant decrease in MDA levels was observed in rats when a dose of omega-3 FAs was given with DOX and a significant increase was determined in the levels of GSH, SOD and GSH-Px activities in serum, liver and kidney tissues, when compared with DOX group. We concluded that omega-3 FA had favorable effects in rat liver and kidney tissues by preventing oxidative damage.
dc.identifier.doi10.1177/0748233713483203
dc.identifier.endpage644
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue7en_US
dc.identifier.pmid23512535
dc.identifier.scopus2-s2.0-84936966955
dc.identifier.scopusqualityQ3
dc.identifier.startpage638
dc.identifier.urihttps://doi.org/10.1177/0748233713483203
dc.identifier.urihttps://hdl.handle.net/20.500.11776/5160
dc.identifier.volume31
dc.identifier.wosWOS:000356981000009
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorTülübaş, Feti
dc.institutionauthorGürel, Ahmet
dc.institutionauthorOran, Mustafa
dc.institutionauthorTopçu, Birol
dc.institutionauthorÇağlar, Veli
dc.institutionauthorUygur, Emine
dc.language.isoen
dc.publisherSage Publications Inc
dc.relation.ispartofToxicology and Industrial Health
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDoxorubicin
dc.subjectoxidative stress
dc.subjectomega-3 fatty acids
dc.subjectliver
dc.subjectkidney
dc.subjectPolyunsaturated Fatty-Acids
dc.subjectInduced Oxidative Stress
dc.subjectEicosapentaenoic Acid
dc.subjectDocosahexaenoic Acid
dc.subjectFish-Oil
dc.subjectLipid-Peroxidation
dc.subjectVitamin-E
dc.subjectToxicity
dc.subjectImpact
dc.subjectLiver
dc.titleThe protective effects of omega-3 fatty acids on doxorubicin-induced hepatotoxicity and nephrotoxicity in rats
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim Yok
İsim:
5160.pdf
Boyut:
129.82 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Sağlık Yüksekokulu Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu