Agmatine, a metabolite of L-arginine, reverses scopolamine-induced learning and memory impairment in rats

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dc.authorid0000-0001-7341-4907
dc.authorid0000-0001-5848-3680
dc.authorscopusid7003362092
dc.authorscopusid11440747800
dc.authorscopusid10240709800
dc.authorscopusid10638814800
dc.authorwosidARICIOGLU, FEYZA/AAR-5704-2020
dc.authorwosidAricioglu, Feyza/ABI-4003-2020
dc.authorwosidUtkan, Tijen/G-2398-2018
dc.authorwosidgocmez, semil selcen/G-2401-2018
dc.contributor.authorUtkan, Tijen
dc.contributor.authorGöçmez, Semil Selcen
dc.contributor.authorRegunathan, Soundararajan
dc.contributor.authorArıcıoğlu, Feyza
dc.date.accessioned2022-05-11T14:41:09Z
dc.date.available2022-05-11T14:41:09Z
dc.date.issued2012
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Tıbbi Farmakoloji Ana Bilim Dalı
dc.description.abstractAgmatine (1-amino-4-guanidino-butane), a metabolite of L-arginine through the action of arginine decarboxylase, is a novel neurotransmitter. In the present study, effects of agmatine on cognitive functions have been evaluated by using one trial step-down passive avoidance and three panel runway task. Agmatine (20, 40, 80 mg/kg i.p.) was administered either in the presence or absence of a cholinergic antagonist, scopolamine (1 mg/kg i.p.). Scopolamine significantly impaired learning and memory in both passive avoidance and three panel runway test. Agmatine did not affect emotional learning, working and reference memory but significantly improved scopolamine-induced impairment of learning and memory in a dose dependent manner. Our results indicate that agmatine, as an endogenous substance, may have an important role in modulation of learning and memory functions. (c) 2012 Elsevier Inc. All rights reserved.
dc.description.sponsorshipResearch Foundation of Kocaeli UniversityKocaeli University [200439]
dc.description.sponsorshipThe present study was supported by the Research Foundation of Kocaeli University (200439) and presented at Society of Biological Psychiatry's 65th Annual Meeting, New Orleans, Louisiana, 20-22 May, 2010.
dc.identifier.doi10.1016/j.pbb.2012.07.003
dc.identifier.endpage584
dc.identifier.issn0091-3057
dc.identifier.issue4en_US
dc.identifier.pmid22796489
dc.identifier.scopus2-s2.0-84864502460
dc.identifier.scopusqualityQ1
dc.identifier.startpage578
dc.identifier.urihttps://doi.org/10.1016/j.pbb.2012.07.003
dc.identifier.urihttps://hdl.handle.net/20.500.11776/9086
dc.identifier.volume102
dc.identifier.wosWOS:000308900200015
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGöçmez, Semil Selcen
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAgmatine
dc.subjectScopolamine
dc.subjectCognition
dc.subjectThree panel runway
dc.subjectPassive avoidance
dc.subjectNitric-Oxide Synthase
dc.subjectMorphine-Withdrawal
dc.subjectCerebral-Ischemia
dc.subjectInduced Seizures
dc.subjectL-Citrulline
dc.subjectBrain
dc.subjectInvolvement
dc.subjectModulation
dc.subjectGlutamate
dc.subjectWorking
dc.titleAgmatine, a metabolite of L-arginine, reverses scopolamine-induced learning and memory impairment in rats
dc.typeArticle

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