Anti-Apoptotic and Anti-Inflammatory Effects of Ginger Extract on Small Intestine Tissue in STZ-Induced Diabetic Rats

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dc.contributor.authorBakir, Buket
dc.date.accessioned2024-10-29T17:59:54Z
dc.date.available2024-10-29T17:59:54Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractIn this study, it was aimed to investigate the effects of the ginger extract on the TNF-a, IL-1(3, bax and bcl-2 expression in the small intestine (duodenum, jejunum and ileum) of rats with experimentally induced diabetes and also, it was examined the ultrastructure of the small intestine by scanning electron microscopy. Wistar albino rats were assigned to five groups as control, sham, ginger, diabetes control, ginger + diabetes. Experimental diabetes was induced by intraperitoneal injection of 50 mg/kg STZ. Ginger and diabetes + ginger group were administered ethanolic ginger extract (200 mg/kg) by oral gavage. In the diabetes control group, it was revealed that intestinal mucosa thickness increased and the villi were folded over each other in the form of a roll and there were disrupted the integrity. Also, while bax, TNF-a, and IL-1(3 expression increased and bcl-2 expression decreased. In the group treated with ginger, both intestinal histologies and bax, bcl-2, TNF-a, and IL-1(3 expressions were similar to that of the control group. It was observed that ginger has regulatory effects on inflammatory and apoptotic proteins in the small intestine in diabetes. Ginger can be evaluated in the treatment of diabetes and may provide new targets for therapeutic intervention.
dc.description.sponsorshipScientific Research Projects Coordinator of Tekirdag Namik Kemal University [NKUBAP.10, 18.147]
dc.description.sponsorshipFunding Support This study was financially supported by Scientific Research Projects Coordinator of Tekirdag Namik Kemal University (project number: NKUBAP.10.GA.18.147) .
dc.identifier.doi10.9775/kvfd.2023.29480
dc.identifier.issn1300-6045
dc.identifier.issn1309-2251
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85167445766
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.9775/kvfd.2023.29480
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14868
dc.identifier.volume29
dc.identifier.wosWOS:001039873300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoen
dc.publisherKafkas Univ, Veteriner Fakultesi Dergisi
dc.relation.ispartofKafkas Universitesi Veteriner Fakultesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectApoptosis
dc.subjectCytokine
dc.subjectDiabetes
dc.subjectScanning electron microscopy
dc.subjectSmall intestine
dc.titleAnti-Apoptotic and Anti-Inflammatory Effects of Ginger Extract on Small Intestine Tissue in STZ-Induced Diabetic Rats
dc.typeArticle

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