Significance of Plasma Irisin, Adiponectin, and Retinol Binding Protein-4 Levels as Biomarkers for Obstructive Sleep Apnea Syndrome Severity

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dc.authoriddurmus, sinem/0000-0002-9272-9098
dc.authoridGelisgen, Remise/0000-0003-4121-5107
dc.authoridUzun, Hafize/0000-0002-1347-8498
dc.contributor.authorFazlioglu, Nevin
dc.contributor.authorUysal, Pelin
dc.contributor.authorDurmus, Sinem
dc.contributor.authorYurt, Sibel
dc.contributor.authorGelisgen, Remise
dc.contributor.authorUzun, Hafize
dc.date.accessioned2024-10-29T17:59:19Z
dc.date.available2024-10-29T17:59:19Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesien_US
dc.description.abstractObjective: Obstructive sleep apnea syndrome (OSAS) is a common sleep disorder that is caused by the reduction or cessation of airflow in the upper airway. Irisin, retinol-binding protein-4 (RBP-4), and adiponectin are the three significant factors in the metabolic process of the human body. The objective of this study was to investigate whether plasma irisin, RBP-4, and adiponectin levels are associated with the severity of OSAS. Methods: According to inclusion and exclusion criteria, 125 patients with OSAS and 46 healthy, gender-matched controls were included in this study. The patients were classified according to the apnea hypopnea index (AHI) as 14 mild cases (5 < AHI < 15), 23 moderate OSAS cases (15 < AHI < 30), and 88 severe OSAS cases (AHI > 30). The plasma irisin, RBP-4, and adiponectin levels were measured and compared between groups. Results: RBP-4 levels were higher in severe OSAS compared to other groups, and irisin levels were significantly lower in severe OSAS compared to other groups. There was a negative correlation between irisin and RBP-4 (r = -0.421; p < 0.001), and irisin and AHI (r = -0.834; p < 0.001), and a positive correlation between irisin and adiponectin (r = 0.240; p = 0.002). There was a negative correlation between RBP-4 and adiponectin (r = -0.507; p < 0.001) and a positive correlation between RBP-4 and AHI (r = 0.473; p < 0.001). As a predictor of OSAS, adiponectin showed the highest specificity (84.8%) and RBP-4 the highest sensitivity (92.0%). Conclusion: Circulating adiponectin, irisin, and RBP-4 may be new biomarkers in OSAS patients in addition to risk factors such as diabetes, obesity, and hypertension. When polysomnography is not available, these parameters and clinical data can be used to diagnose the disease. As a result, patients with an AHI score greater than thirty should be closely monitored for metabolic abnormalities.en_US
dc.identifier.doi10.3390/biom13101440
dc.identifier.issn2218-273X
dc.identifier.issue10en_US
dc.identifier.pmid37892122en_US
dc.identifier.scopus2-s2.0-85175015038en_US
dc.identifier.urihttps://doi.org/10.3390/biom13101440
dc.identifier.urihttps://hdl.handle.net/20.500.11776/14701
dc.identifier.volume13en_US
dc.identifier.wosWOS:001098228700001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMdpien_US
dc.relation.ispartofBiomoleculesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectobstructive sleep apneaen_US
dc.subjectirisinen_US
dc.subjectretinol-binding protein-4en_US
dc.subjectadiponectinen_US
dc.subjectapnea hypopnea indexen_US
dc.titleSignificance of Plasma Irisin, Adiponectin, and Retinol Binding Protein-4 Levels as Biomarkers for Obstructive Sleep Apnea Syndrome Severityen_US
dc.typeArticleen_US

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