Mining database for the clinical significance, prognostic value and expression of miR-4746 in hepatocellular carcinoma

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dc.contributor.authorAltan, Zekiye
dc.contributor.authorSahın, Yunus
dc.contributor.authorKarabulut, Aydın
dc.contributor.authorArslan, Ahmet
dc.date.accessioned2024-10-29T17:50:36Z
dc.date.available2024-10-29T17:50:36Z
dc.date.issued2023
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractAbstract Objective: MicroRNAs (miRNAs) are key regulators in the progression and development of hepatocellular carcinoma (HCC). In recent study the miR-4746 was found to be overexpressed in HCC, however, differential expression pattern and clinicopathological significance of miR-4746 in HCC remains unclear. In current study we aimed to evaluate expression profile, clinicopathological role and prognostic value of miR-4746 by using computational approaches. Material and Methods: The expression profile of miR-4746 in various human cancers was determined using the dbDEMC database. Also, we used ENCORI/Starbase v2 and UALCAN databases to analyze miR-4746 expression level in HCC. Moreover, we investigated clinicopathological function of miR-4746 by using UALCAN database. Finally, survival analysis was performed to determine prognostic significance of miR-4746 in HCC by Kaplan-Meier plotter and ENCORI/Starbase v2 databases. Results: The miR-4746 had differential expression patterns in various human cancers and was significantly upregulated in HCC tissues compared with normal samples. Clinicopathological analysis revealed that, miR-4746 was differentially expressed in different clinical parameters including cancer stage, tumor grade, nodal metastasis status, TP53 mutation status, and patient’s age. In addition, high expression of miR-4746 was significantly correlated with poor prognosis in HCC. Conclusion: Our findings indicated that miR-4746 might be as an oncogenic miRNA which were correlated with poor prognosis and worse clinicopathological outcomes. Furthermore, miR-4746 might have an important role in tumorigenesis of HCC and it might serve as potential prognostic biomarker.
dc.identifier.doi10.31832/smj.1187165
dc.identifier.endpage222
dc.identifier.issn2146-409X
dc.identifier.issue2en_US
dc.identifier.startpage216
dc.identifier.trdizinid1186918
dc.identifier.urihttps://doi.org/10.31832/smj.1187165
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/1186918
dc.identifier.urihttps://hdl.handle.net/20.500.11776/13079
dc.identifier.volume13
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.relation.ispartofSakarya Tıp Dergisi
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectMiRNA
dc.subjectprognosis
dc.subjectbioinformatics
dc.subjecthepatocellular carcinoma
dc.subjectmiR-4746
dc.titleMining database for the clinical significance, prognostic value and expression of miR-4746 in hepatocellular carcinoma
dc.typeArticle

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