Isolation of new isoflavonoids derivatives from Genista carinalis Griseb. and biological activity

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dc.authoridOzturk, Mehmet/0000-0001-8932-4535
dc.authoridARGON, MERVE/0000-0001-8108-5509
dc.authoridCAKIR, CANSEL/0000-0002-6175-9008
dc.contributor.authorCaliskan, Hilmican
dc.contributor.authorSabudak, Temine
dc.contributor.authorOrak, H. Hulya
dc.contributor.authorArgon, Merve
dc.contributor.authorCakir, Cansel
dc.contributor.authorOzturk, Mehmet
dc.date.accessioned2025-04-06T12:23:51Z
dc.date.available2025-04-06T12:23:51Z
dc.date.issued2024
dc.departmentTekirdağ Namık Kemal Üniversitesi
dc.description.abstractThe genus Genista L. has been used in the treatment of rheumatic, diabetic and ulcerous diseases. Herein, the antioxidant, anticholinesterase, and antidiabetic activities of Genista carinalis Griseb. extracts were determined. The antioxidant activity was performed FRAP, DPPH, CUPRAC, and TEAC assays, while anticholinesterase activity was performed against acetylcholinesterase and butyrylcholinesterase, and antidiabetic activity against alpha-amylase and alpha-glucosidase, spectrophotometrically. The activity results allowed for the study of the phytochemistry of the ethyl acetate extract that exhibited the best activity. Three new isoflavonoids, 5-methyl-7-methoxy-4 '-hydroxy isoflavone (3), 7-acetyl-5-hydroxy-4 '-methoxy isoflavone (4) and 7-O-[beta-D-glucopyranosyl-(6 ''-> 6 ''')-beta-D-glucopyranosyl]-5-4 '-dihydroxy isoflavone (5), together with two known compounds, isoprunetin (1) and 6-hydroxy biochanin A (2) were isolated from the ethyl acetate extract. Their structures were elucidated by extensive 1D-, 2D-NMR, and MS data analyses. Compound (3) showed the highest antioxidant potential in TEAC, FRAP, and CUPRAC assays, while (2) exhibited higher butyrylcholinesterase enzyme inhibitory activity among the isolated compounds.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Tekirdag Namik Kemal University [NKUBAP.01.DR.22.352]
dc.description.sponsorshipThis study was funded by the Scientific Research Projects Coordination Unit of Tekirdag Namik Kemal University. Project number: NKUBAP.01.DR.22.352.
dc.identifier.doi10.1080/14786419.2024.2427806
dc.identifier.issn1478-6419
dc.identifier.issn1478-6427
dc.identifier.pmid39535754
dc.identifier.scopus2-s2.0-85209634941
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1080/14786419.2024.2427806
dc.identifier.urihttps://hdl.handle.net/20.500.11776/17203
dc.identifier.wosWOS:001355056100001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofNatural Product Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20250406
dc.subjectGenista carinalis
dc.subjectisoflavonoids
dc.subjectantioxidant activity
dc.subjectanticholinesterase activity
dc.subjectalpha-amylase inhibitory activity
dc.subjectalpha-glucosidase inhibitory activity
dc.titleIsolation of new isoflavonoids derivatives from Genista carinalis Griseb. and biological activity
dc.typeArticle

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