Cervical Priming Before Diagnostic Operative Hysteroscopy in Infertile Women: A Randomized, Double-Blind, Controlled Comparison of 2 Vaginal Misoprostol Doses

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dc.authorid0000-0003-3728-3414
dc.authorid0000-0003-0810-6195
dc.authorscopusid55022842500
dc.authorscopusid24075279000
dc.authorscopusid43261603500
dc.authorscopusid55347075400
dc.authorscopusid56089822500
dc.authorscopusid6602816744
dc.authorwosidozgor, bahar yuksel/ABB-2921-2020
dc.authorwosidBastu, Ercan/K-5354-2017
dc.contributor.authorBastu, Ercan
dc.contributor.authorÇelik, Cem
dc.contributor.authorNehir, Asli
dc.contributor.authorDoğan, Murat
dc.contributor.authorYüksel, Bahar
dc.contributor.authorErgun, Bülent
dc.date.accessioned2022-05-11T14:35:51Z
dc.date.available2022-05-11T14:35:51Z
dc.date.issued2013
dc.departmentFakülteler, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kadın Hastalıkları ve Doğum Ana Bilim Dalı
dc.description.abstractThe aim of this study was to evaluate the efficacy of vaginal misoprostol for cervical priming at doses of 200 mcg and 400 mcg, 12 to 15 hours before diagnostic office hysteroscopy (OH) without anesthesia in patients with infertility. Sixty infertile patients requiring a diagnostic office hysteroscopy for investigation of infertility were included in the study. The patients were randomly allocated into 3 vaginally administered misoprostol groups: (1) control group, (2) 200-mcg dose group, and (3) 400-mcg dose group. Misoprostol significantly facilitated the procedure of OH: cervical entry was easier; procedural time was shorter; baseline cervical width was larger; and pain scoring was lower in the misoprostol groups compared with the control group. Increasing the dose of misoprostol from 200 mcg to 400 mcg did not improve the effect on cervical dilation. Misoprostol is a promising analog to use for cervical priming before OH. Since doses of 200 mcg and 400 mcg vaginal misoprostol 12 hours before the OH both have proven to be effective regimens, 200 mcg may be preferred. However, before routine clinical usage, further research is needed through large, randomized, controlled trials powered to detect a difference in complications to determine whether misoprostol reduces complications in OH.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Istanbul UniversityIstanbul University [26324]
dc.description.sponsorshipAn earlier version of this research was presented at the 42nd Annual Meeting of American Society of Reproductive Medicine in San Diego, 2012. This was made possible by funding from the Scientific Research Projects Coordination Unit of Istanbul University (grant 26324).
dc.identifier.doi10.9738/INTSURG-D-12-00024.1
dc.identifier.endpage144
dc.identifier.issn0020-8868
dc.identifier.issue2en_US
dc.identifier.pmid23701149
dc.identifier.scopus2-s2.0-84897129956
dc.identifier.scopusqualityQ4
dc.identifier.startpage140
dc.identifier.urihttps://doi.org/10.9738/INTSURG-D-12-00024.1
dc.identifier.urihttps://hdl.handle.net/20.500.11776/8259
dc.identifier.volume98
dc.identifier.wosWOS:000325749700008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorÇelik, Cem
dc.language.isoen
dc.publisherInt College Of Surgeons
dc.relation.ispartofInternational Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCervical priming
dc.subjectMisoprostol
dc.subjectOffice hysteroscopy
dc.subjectPremenopausal Women
dc.subjectControlled-Trial
dc.subjectPlacebo
dc.titleCervical Priming Before Diagnostic Operative Hysteroscopy in Infertile Women: A Randomized, Double-Blind, Controlled Comparison of 2 Vaginal Misoprostol Doses
dc.typeArticle

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