Assessment of intracellular zinc levels in infants with food protein-induced allergic proctocolitis

Basit Öğe Kaydı
dc.authoridÇELIKKOL, ALIYE/0000-0002-3799-4470
dc.authorwosidÇELIKKOL, ALIYE/ABE-2695-2020
dc.contributor.authorGünaydın, Nurşen Ciğerci
dc.contributor.authorÇelikkol, Aliye
dc.contributor.authorNalbantoğlu, Ayşin
dc.date.accessioned2023-05-06T17:18:25Z
dc.date.available2023-05-06T17:18:25Z
dc.date.issued2023
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalı
dc.departmentFakülteler, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
dc.description.abstractBackground: Food protein-induced allergic proctocolitis (FPIAP) is characterized by bloody stools in well-appearing infants. Zinc is a micronutrient that plays a crucial role in immune modulation and is essential for cellular function during immune response. Although there are studies on the assessment of intracellular zinc levels in allergic diseases, no data is available on erythrocyte zinc levels of patients with FPIAP. Objective: This study aimed to assess the erythrocyte zinc levels of children with allergic proctocolitis and compare zinc levels with clinical and demographic characteristics. Methods: This was a case-control study that prospectively compared 50 patients with FPIAP and 50 healthy children without malnutrition. The erythrocyte zinc levels of children were determined using atomic absorption spectrophotometry. Results: Fifty patients with FPIAP, including 28 (51%) girls, with median age of 7.1 +/- 2.9 (3-14) months and 50 healthy children, including 26 (53.1%) girls, with median age of 7.7 +/- 2.8 (3-13) months were included in the study. Seventy percent (n = 35) of the patients with FPIAP started to have symptoms while they were exclusively breastfeeding. Offending allergen foods were cow's milk (78%), egg (40%), sesame (10%), hazelnut (8%), almond (6%), beef (6%), and peanuts (6%, n = 3). Intracellular (erythrocyte) zinc levels in patients with FPIAP were lower than in the healthy control group (495.5 +/- 134 mu g/dL, 567.3 +/- 154.4 mu g/dL, respectively, P = 0.01). Patients with FPIAP aged younger than 6 months had lower intracellular zinc levels compared with those aged above 6 months (457 +/- 137 mu g/dL; 548 +/- 112 mu g/dL, respectively, P = 0.01). There was no relationship between zinc levels and time of symptom onset, presence of concomitant disease, being allergic to multiple foods, and family history of atopy (P > 0.05). Conclusions: FPIAP is a food allergy with limited information on its pathogenesis. Considering the beneficial effects on gastrointestinal system epithelia, zinc may be involved in the patho-genesis of FPIAP. Future comprehensive prospective research on this subject is of importance. (c) 2023 Codon Publications. Published by Codon Publications.
dc.identifier.doi10.15586/aei.v51i1.660
dc.identifier.endpage15
dc.identifier.issn0301-0546
dc.identifier.issn1578-1267
dc.identifier.issue1en_US
dc.identifier.pmid36617816
dc.identifier.scopus2-s2.0-85145968456
dc.identifier.scopusqualityQ3
dc.identifier.startpage9
dc.identifier.urihttps://doi.org/10.15586/aei.v51i1.660
dc.identifier.urihttps://hdl.handle.net/20.500.11776/11815
dc.identifier.volume51
dc.identifier.wosWOS:000910922200002
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorGünaydın, Nurşen Ciğerci
dc.institutionauthorÇelikkol, Aliye
dc.institutionauthorNalbantoğlu, Ayşin
dc.language.isoen
dc.publisherCodon Publications
dc.relation.ispartofAllergologia Et Immunopathologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAllergic Proctocolitis
dc.subjectChildren
dc.subjectErythrocyte Zinc
dc.subjectFood Allergy
dc.subjectTrace Element
dc.subjectInduced Enterocolitis Syndrome
dc.subjectChildren
dc.subjectSupplementation
dc.subjectDiagnosis
dc.subjectSelenium
dc.subjectBarrier
dc.subjectColitis
dc.titleAssessment of intracellular zinc levels in infants with food protein-induced allergic proctocolitis
dc.typeArticle

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
Küçük Resim
İsim:
11815.pdf
Boyut:
827.78 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Tam Metin / Full Text
İndir

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
Tıp Fakültesi Koleksiyonu