A novel vibrotactile system for stimulating the glabrous skin of awake freely behaving rats during operant conditioning

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dc.authorid0000-0003-4119-617X
dc.authorid0000-0002-7757-5764
dc.authorscopusid55597343100
dc.authorscopusid6603560243
dc.authorwosidDEVECIOGLU, ISMAIL/H-4523-2018
dc.contributor.authorDevecioğlu, İsmail
dc.contributor.authorGüçlü, Burak
dc.date.accessioned2022-05-11T14:16:01Z
dc.date.available2022-05-11T14:16:01Z
dc.date.issued2015
dc.departmentFakülteler, Çorlu Mühendislik Fakültesi, Biyomedikal Mühendisliği Bölümü
dc.description.abstractBackground: Rat skin is innervated by mechanoreceptive fibers similar to those in other mammals. Tactile experiments with behaving rats mostly focus on the vibrissal system which does not exist in humans. The aim of this study was to design and implement a novel vibrotactile system to stimulate the glabrous skin of behaving rats during operant conditioning. New method: A computer-controlled vibrotactile system was developed for various tasks in which the volar surface of unrestrained rats' fore- and hindpaws was stimulated in an operant chamber. Results: The operant chamber was built from off-the-shelf components. A highly accurate electrodynamic shaker with a novel multi-probe design was used for generating mechanical displacements. Twenty-five rats were trained for four sequential tasks: (A) middle-lever (trial start signal) press, (B) side-lever press with an associated visual cue, (C) similar to (B) with the addition of an auditory/tactile stimulus, (D) auditory/tactile detection (yes/no) task. Out of 9 rats which could complete the tactile version of this training schedule, 5 had over 70% accuracy in the tactile version of the detection task. Comparison with existing methods: Unlike actuators for stimulating whiskers, this system does not require a particular head/body alignment and can be used with freely behaving animals. Conclusions: The vibrotactile system was found to be effective for conditioning freely behaving rats based on stimuli applied on the glabrous skin. However, detection accuracies were lower compared to those in tasks involving whisker stimulation reported previously, probably due to differences in cortical processing. (C) 2015 Elsevier B.V. All rights reserved.
dc.description.sponsorshipMinistry of Development DPT project [09K120520]; Bogazici University BAPBogazici University [13XP8]; TUBITAK grantTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [113S901]
dc.description.sponsorshipThis study was supported by Ministry of Development DPT project no: 09K120520, Bogazici University BAP no: 13XP8, and TUBITAK grant no: 113S901. We would like to thank Bige Vardar, caglar Gok, Mehmet Kocaturk and Sedef Yusufogullari for their help in the experiments, and Ahmet Turan Talas, Bora Buyuksarac and Erhan Uyanik for their help in the construction of the operant chamber.
dc.identifier.doi10.1016/j.jneumeth.2015.01.004
dc.identifier.endpage51
dc.identifier.issn0165-0270
dc.identifier.issn1872-678X
dc.identifier.pmid25593046
dc.identifier.scopus2-s2.0-84921328669
dc.identifier.scopusqualityQ2
dc.identifier.startpage41
dc.identifier.urihttps://doi.org/10.1016/j.jneumeth.2015.01.004
dc.identifier.urihttps://hdl.handle.net/20.500.11776/6152
dc.identifier.volume242
dc.identifier.wosWOS:000350921900003
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorDevecioğlu, İsmail
dc.language.isoen
dc.publisherElsevier Science Bv
dc.relation.ispartofJournal of Neuroscience Methods
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectOperant conditioning
dc.subjectVibrotactile stimulus
dc.subjectRat glabrous skin
dc.subjectAnimal psychophysics
dc.subjectAdapting Mechanoreceptive Fibers
dc.subjectReceptive-Field Characteristics
dc.subjectPrimary Somatosensory Cortex
dc.subjectHairy Skin
dc.subjectSensorimotor System
dc.subjectSpatial Summation
dc.subjectWhisker System
dc.subjectDiscrimination
dc.subjectFrequency
dc.subjectUnits
dc.titleA novel vibrotactile system for stimulating the glabrous skin of awake freely behaving rats during operant conditioning
dc.typeArticle

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